Four New Caryophyllene Sesquiterpenoids Isolated from Hypholoma apnoides 819.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-11-29 DOI:10.1002/cbdv.202402414

Yu-Ting Wang, Yuan Dong, Fang Wang, Shuai-Ming Zhu, Yang Zhang, Yu Yang, Rui Xu, Cai-Hong Dong, You-Zhi Zhang, Chang-Wei Li

引用次数: 0

Abstract

Four previously undescribed caryophyllene sesquiterpenoids (1-4) along with one known drimane sesquiterpenoid (5) were isolated from the fermentation products of the mushroom Hypholoma capnoides 819. The structures of 1-4 with rare tricyclic skeleton (6/5/4) or bicyclic skeletons (9/4) were determined on the basis of comprehensive spectroscopic data analysis, calculated NMR, ORD data and their biosynthetic pathways. Compounds 1-5 only showed very weak cytotoxicity towards mouse microglial cells (BV2), breast cancer cells (MCF-7) and human lung cancer cells (A549) at 40 μM. Additionally, none of the compounds demonstrated antibacterial activity against Staphylococcus aureus or Escherichia coli at 128 μg/mL.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.