Ag@polydopamine-functionalized borate ester-linked chitosan hydrogel integrates monitoring with wound healing for epidermal sensor

IF 12.3 1区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

npj Flexible Electronics Pub Date : 2024-11-30 DOI:10.1038/s41528-024-00366-4

Wei Shi, Hui Li, Chengsheng Xu, Gaoyi Wu, Jing Chen, Jinyong Zhang, Lixin Liang, Qingyang Wu, Yongsheng Liang, Guanglin Li, Wei Tang

{"title":"Ag@polydopamine-functionalized borate ester-linked chitosan hydrogel integrates monitoring with wound healing for epidermal sensor","authors":"Wei Shi, Hui Li, Chengsheng Xu, Gaoyi Wu, Jing Chen, Jinyong Zhang, Lixin Liang, Qingyang Wu, Yongsheng Liang, Guanglin Li, Wei Tang","doi":"10.1038/s41528-024-00366-4","DOIUrl":null,"url":null,"abstract":"Flexible sensors are promising candidates in personalized healthcare, while desired sensors that allow implantation for biomedical applications with optimal sensing and favorable biological properties remain challenges. Here, a multifunctional hydrogel sensor was developed with gallic acid-modified chitosan (CSGA) and 3-carboxyphenylboronic acid-modified chitosan (CSPBA) by encapsulating Ag-decorated polydopamine (Ag@PDA) nanoparticles, namely Ag@PDA-(CSPBA/CSGA). The optimized hydrogel sensor showed desired sensitivity (gauge factor = 2.49), a rapid response/recovery time of 263 ms and good durability. Due to the presence of abundant reactive groups within Ag@PDA-(CSPBA/CSGA), the hydrogel sensor exhibited a comprehensive performance of self-healing, tissue adhesiveness, antioxidative activity, and antibacterial effects against Escherichia coli (92.76%) and Staphylococcus aureus (98.08%). Moreover, the hydrogel sensor could be utilized as a wound dressing, facilitating accelerated wound closure and tissue regeneration. Both subtle activities and large-scale movements could be monitored and distinguished by the hydrogel sensor. This study provides a promising epidermal sensor that offers multifunctionality for health monitoring and wound management.","PeriodicalId":48528,"journal":{"name":"npj Flexible Electronics","volume":" ","pages":"1-12"},"PeriodicalIF":12.3000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41528-024-00366-4.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Flexible Electronics","FirstCategoryId":"88","ListUrlMain":"https://www.nature.com/articles/s41528-024-00366-4","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Flexible sensors are promising candidates in personalized healthcare, while desired sensors that allow implantation for biomedical applications with optimal sensing and favorable biological properties remain challenges. Here, a multifunctional hydrogel sensor was developed with gallic acid-modified chitosan (CSGA) and 3-carboxyphenylboronic acid-modified chitosan (CSPBA) by encapsulating Ag-decorated polydopamine (Ag@PDA) nanoparticles, namely Ag@PDA-(CSPBA/CSGA). The optimized hydrogel sensor showed desired sensitivity (gauge factor = 2.49), a rapid response/recovery time of 263 ms and good durability. Due to the presence of abundant reactive groups within Ag@PDA-(CSPBA/CSGA), the hydrogel sensor exhibited a comprehensive performance of self-healing, tissue adhesiveness, antioxidative activity, and antibacterial effects against Escherichia coli (92.76%) and Staphylococcus aureus (98.08%). Moreover, the hydrogel sensor could be utilized as a wound dressing, facilitating accelerated wound closure and tissue regeneration. Both subtle activities and large-scale movements could be monitored and distinguished by the hydrogel sensor. This study provides a promising epidermal sensor that offers multifunctionality for health monitoring and wound management.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

npj Flexible Electronics Multiple-

CiteScore

17.10

自引率

4.80%

发文量

审稿时长

6 weeks

期刊介绍： npj Flexible Electronics is an online-only and open access journal, which publishes high-quality papers related to flexible electronic systems, including plastic electronics and emerging materials, new device design and fabrication technologies, and applications.