ENDOSCOPIC ENDONASAL TRANS-SPHENOIDAL SURGERY IN PATIENTS WITH MACRO-ADENOMA EXTENT OF SURGICAL RESECTION AND RECURRENCE RATE.

Zia Ur Rahman, Muhammad Idris Khan, Muhammad Aamir
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Abstract

Background: Endoscopic Endonasal Trans-Sphenoidal Approach has been employed for skull base tumours especially macro-adenomas, for the last decade in our setup. Here we are sharing our experience with the EETA for patients with micro-adenomas in terms of extent of tumour resection and its recurrence. The objective was to assess endoscopic endonasal trans-sphenoidal surgery in patients with macro-adenoma for extent of surgical resection and recurrence rate.

Methods: This descriptive case series study was carried out from May 2021 till April 2023. Male and female patients with macroadenoma were enrolled which was diagnosed with contrast enhanced volumetric MRI brain. EETA and resection was performed. Extent of resection recurrence was confirmed on post-op MRI and follow up at 6 months respectively.

Results: A total of 58 patients were enrolled. Mean age of the patients was 47.51±7.93 years and male to female ratio was 1.3: 1. 42 (72.4%) tumours were non-functional. Somatotropin releasing tumour was the most common functional tumour (n=09, 15.5%). Total resection was performed in 49 (84.4%) patients. Recurrence was observed in 9 (15.6%) cases.

Conclusions: EETA has been shown to be a safe and effective technique for the resection of macroadenoma of the skull base.

经鼻内窥镜蝶窦手术治疗大腺瘤患者手术切除范围及复发率。
背景:在过去的十年里,经鼻内经蝶窦入路已被用于颅底肿瘤尤其是大腺瘤的治疗。在此,我们将分享我们在微腺瘤患者的肿瘤切除程度和复发方面的经验。目的是评估经鼻内窥镜蝶窦手术治疗大腺瘤的手术切除范围和复发率。方法:描述性病例系列研究于2021年5月至2023年4月进行。研究对象为男性和女性大腺瘤患者,均采用脑磁共振造影增强成像进行诊断。行EETA和手术切除。术后MRI和随访6个月分别确认切除复发程度。结果:共入组58例患者。患者平均年龄47.51±7.93岁,男女比例为1.3:1。非功能性肿瘤42例(72.4%)。促生长激素释放肿瘤是最常见的功能性肿瘤(n=09, 15.5%)。49例(84.4%)患者行全切除。9例(15.6%)复发。结论:EETA是一种安全有效的颅底大腺瘤切除术技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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