Regulatory Effect of PDGF/PDGFR on Hematopoiesis.

IF 3.6 2区医学 Q2 HEMATOLOGY

Seminars in thrombosis and hemostasis Pub Date : 2024-11-28 DOI:10.1055/s-0044-1796630

Yong Liu, Junbin Huang, Lindi Li, Yifei Duan, Beng H Chong, Liang Li, Mo Yang

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引用次数: 0

Abstract

Platelet-derived growth factor (PDGF) is a critical cytokine with substantial regulatory effects on hematopoiesis. Recent research highlights the essential role of PDGF in the modulation of hematopoietic stem/progenitor cells (HSPCs), megakaryocytes/platelets, and thrombopoietin (TPO) synthesis within the bone marrow microenvironment. PDGF directly stimulates the proliferation and differentiation of HSPCs while also inhibiting apoptosis. In addition, PDGF indirectly enhances the production of other growth factors, including granulocyte-macrophage colony-stimulating factors. Further, PDGF regulates TPO production and influences the bone marrow milieu, thus impacting hematopoiesis and platelet formation. Mechanistically, PDGF binds to its receptor, PDGF receptor (PDGFR), thus activating the PDGF/PDGFR signaling pathway. This pathway subsequently activates phosphoinositide 3-kinase/protein kinase B, leading to the activation of downstream cytokines, including c-Fos and NF-E2, while inhibiting caspase-3 activation. Collectively, these actions have prodifferentiation and antiapoptotic effects on megakaryocytes, thereby regulating platelet production. This review provides a comprehensive analysis of the regulatory role of the PDGF/PDGFR axis in hematopoiesis, with a particular focus on platelet production, by summarizing all studies on PDGF/PDGFR from our group and globally.

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PDGF/PDGFR对造血功能的调节作用。

血小板衍生生长因子（PDGF）是一种重要的细胞因子，在造血过程中具有重要的调节作用。最近的研究强调了PDGF在骨髓微环境中调节造血干细胞/祖细胞（HSPCs）、巨核细胞/血小板和血小板生成素（TPO）合成中的重要作用。PDGF直接刺激HSPCs的增殖和分化，同时抑制凋亡。此外，PDGF间接促进其他生长因子的产生，包括粒细胞-巨噬细胞集落刺激因子。此外，PDGF调节TPO的产生并影响骨髓环境，从而影响造血和血小板形成。在机制上，PDGF与其受体PDGF受体（PDGFR）结合，从而激活PDGF/PDGFR信号通路。该途径随后激活磷酸肌苷3-激酶/蛋白激酶B，导致下游细胞因子的激活，包括c-Fos和NF-E2，同时抑制caspase-3的激活。总的来说，这些作用对巨核细胞具有促分化和抗凋亡作用，从而调节血小板的产生。这篇综述通过总结我们团队和全球关于PDGF/PDGFR的所有研究，全面分析了PDGF/PDGFR轴在造血中的调节作用，特别关注血小板的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in thrombosis and hemostasis 医学-外周血管病

CiteScore

8.80

自引率

21.10%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Seminars in Thrombosis and Hemostasis is a topic driven review journal that focuses on all issues relating to hemostatic and thrombotic disorders. As one of the premiere review journals in the field, Seminars in Thrombosis and Hemostasis serves as a comprehensive forum for important advances in clinical and laboratory diagnosis and therapeutic interventions. The journal also publishes peer reviewed original research papers. Seminars offers an informed perspective on today''s pivotal issues, including hemophilia A & B, thrombophilia, gene therapy, venous and arterial thrombosis, von Willebrand disease, vascular disorders and thromboembolic diseases. Attention is also given to the latest developments in pharmaceutical drugs along with treatment and current management techniques. The journal also frequently publishes sponsored supplements to further highlight emerging trends in the field.