Elevated Iliac Calcium Score as a Marker of Coronary Calcification and Overall Atherosclerotic Risk

IF 1.4 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Annals of vascular surgery Pub Date : 2025-02-01 DOI:10.1016/j.avsg.2024.10.023

M.a Lourdes Del Río-Solá , Irene Martin-Morquecho , Ana Revilla-Orodea , Israel Sánchez-Lite

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Abstract

Background

The initial assessment of cardiovascular risk in patients undergoing lower limb revascularization surgery is crucial to minimize complications and improve outcomes. This study aims to determine if the iliac calcium score (ICS) serves as a cardiologic risk marker by examining its correlation with the coronary calcium score (CCS) in these patients.

Methods

This prospective observational single-center study included 248 patients with critical limb ischemia undergoing revascularization procedures from January 2022 to June 2023. Baseline characteristics such as age, gender, smoking status, comorbidities, and clinical status were recorded. CCS and ICS were calculated using preoperative computed tomography angiography. Multiple linear regression identified significant predictors of ICS, including CCS, iliac intima-media thickness (i-IMT), coronary artery disease, diabetes, chronic kidney disease, hypertension, dyslipidemia, and smoking.

Results

The study population had a mean age of 74.4 years, 83.86% male. Significant correlations were found between ICS and CCS (Pearson r = 0.34, P < 0.001) and between ICS and i-IMT (Pearson r = 0.35, P < 0.001). Regression analysis revealed significant predictors for ICS, including CCS (coefficient = 1.808, P < 0.0001), i-IMT (coefficient = 3.11, P < 0.0001), coronary artery disease (coefficient = 11.94, P = 0.042), diabetes (coefficient = 19.59, P = 0.002), chronic kidney disease (coefficient = 11.79, P < 0.0001), and hypertension (coefficient = 22.10, P = 0.001). Dyslipidemia and smoking did not show significant associations with ICS.

Conclusions

The ICS shows a statistically significant association with the CCS and i-IMT in patients undergoing lower limb revascularization surgery. This correlation suggests that ICS reflects vascular calcification patterns like those observed in coronary arteries. Further studies are needed to explore this relationship in diverse patient populations and under varying clinical conditions.

Abstract Image

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升高的髂钙评分作为冠状动脉钙化和整体动脉粥样硬化风险的标志。

背景：对接受下肢血运重建术的患者进行心血管风险的初步评估对于减少并发症和改善预后至关重要。本研究旨在通过检查这些患者的髂钙评分（ICS）与冠状动脉钙评分（CCS）的相关性来确定其是否可作为心脏病危险标志物。方法：这项前瞻性观察性单中心研究纳入了248例危重肢体缺血患者，于2022年1月至2023年6月接受了血运重建术。记录基线特征，如年龄、性别、吸烟状况、合并症和临床状况。术前ct血管造影计算CCS和ICS。多元线性回归确定了ICS的显著预测因素，包括CCS、髂内膜-中膜厚度（i-IMT）、冠状动脉疾病（CAD）、糖尿病、慢性肾脏疾病（CKD）、高血压、血脂异常和吸烟。结果：研究人群平均年龄74.4岁，男性83.86%。结论：下肢血运重建术患者的髂钙评分与冠状动脉钙评分、髂内膜-中膜厚度存在显著相关性。这种相关性表明髂钙评分反映了血管钙化模式，就像冠状动脉中观察到的那样。需要进一步的研究来探索不同患者群体和不同临床条件下的这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of vascular surgery 医学-外科

CiteScore

3.00

自引率

13.30%

发文量

603

审稿时长

50 days

期刊介绍： Annals of Vascular Surgery, published eight times a year, invites original manuscripts reporting clinical and experimental work in vascular surgery for peer review. Articles may be submitted for the following sections of the journal: Clinical Research (reports of clinical series, new drug or medical device trials) Basic Science Research (new investigations, experimental work) Case Reports (reports on a limited series of patients) General Reviews (scholarly review of the existing literature on a relevant topic) Developments in Endovascular and Endoscopic Surgery Selected Techniques (technical maneuvers) Historical Notes (interesting vignettes from the early days of vascular surgery) Editorials/Correspondence