Maternal Serum Iodine Concentrations in Early Pregnancy Exhibited Well Diagnostic Ability for Thyroid Dysfunction, Inverse Associations with Gestational Weight Gain, and Birth Size: Longitudinal Analyses Based on Huizhou Mother-Infant Cohort.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhao-Min Liu, Huan-Huan Long, Dan Li, Ai-Ping Fang, Chao-Gang Chen, Cheng Wang, Min-Min Li, Yi Wu, Su-Juan Zhang, Wen-Jing Pan
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Abstract

The study aims to explore the associations of maternal serum iodine concentrations (SIC) with thyroid function, obstetric, and birth outcomes. This was a prospective study embedded in the Huizhou Mother-Infant Cohort. Singleton mothers aged 18-45 years were enrolled at their first antenatal visits. Maternal SIC and thyroid markers were tested by inductively coupled plasma mass spectrometry and electronic chemiluminescent assay, respectively. Obstetric and birth outcomes were retrieved from the Hospital Information System. Two nested 1:1 age and body mass index-matched case-control studies were embedded in the cohort including 224 pairs of mothers with gestational diabetes mellitus (GDM) and 302 paired of newborns with small for gestational age (SGA) and their respective healthy controls. Multivariable linear and conditional logistic regression models were applied to explore the relationship of maternal SIC with obstetric complications and birth outcomes. A total of 1558 mothers were included for analysis. Receiver operating characteristic curve (ROC) analysis showed that maternal SIC in the 1st trimester (T1) had well diagnostic ability for clinical and subclinical hyperthyroidism, clinical hypothyroidism, and hypothyroxinemia with the areas under the curve of 0.907, 0.734, 0.867, and 0.927, respectively (all p < 0.05). Mothers in the highest quartile of SIC at T1 had an increased risk of SGA (OR = 2.043, 95% CI: 1.198-3.483, p = 0.009) but not for GDM risk. Maternal SIC were significantly and inversely associated with gestational weight gain (GWG), birth weight, and Ponderal index (all p < 0.05). SIC at T1 had well diagnostic values for thyroid dysfunction. High gestational SIC during early pregnancy were associated with lowered GWG, birth size, and increased risk of SGA. Study registration no: NCT03922087 at Clinicaltrial.gov.com.

妊娠早期孕妇血清碘浓度对甲状腺功能障碍具有良好的诊断能力,与妊娠体重增加和出生尺寸呈负相关:基于惠州母婴队列的纵向分析。
本研究旨在探讨产妇血清碘浓度(SIC)与甲状腺功能、产科和分娩结局的关系。本研究为惠州母婴队列前瞻性研究。年龄在18-45岁的单身母亲在第一次产前检查时被登记。采用电感耦合血浆质谱法和电子化学发光法分别检测母体SIC和甲状腺标志物。从医院信息系统检索产科和分娩结果。本研究纳入了两项巢式1:1年龄和体重指数匹配的病例对照研究,包括224对患有妊娠期糖尿病(GDM)的母亲和302对小于胎龄(SGA)的新生儿及其各自的健康对照。应用多变量线性和条件logistic回归模型探讨产妇SIC与产科并发症和分娩结局的关系。共有1558名母亲被纳入分析。受试者工作特征曲线(ROC)分析显示,孕早期母体SIC对临床及亚临床甲状腺功能亢进、临床甲状腺功能减退、甲状腺功能减退有较好的诊断能力,曲线下面积分别为0.907、0.734、0.867、0.927(均p
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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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