Recent progress on anti-cancer activity of thiadiazoles: A review

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2024-11-26 DOI:10.1016/j.rechem.2024.101939

C.R. Santhosh , Sampath Chinnam , Nagaraju Kottam , Amreen S , Guddekoppa S. Ananthnag , G.M. Madhu , Samata Gadde , Viola Tressa Fernandes , Haritha Arnipalli

{"title":"Recent progress on anti-cancer activity of thiadiazoles: A review","authors":"C.R. Santhosh , Sampath Chinnam , Nagaraju Kottam , Amreen S , Guddekoppa S. Ananthnag , G.M. Madhu , Samata Gadde , Viola Tressa Fernandes , Haritha Arnipalli","doi":"10.1016/j.rechem.2024.101939","DOIUrl":null,"url":null,"abstract":"<div><div>Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101939"},"PeriodicalIF":2.5000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211715624006350","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties.

Abstract Image

查看原文本刊更多论文

噻二唑类抗癌活性研究进展综述

癌症是一种危及生命的疾病，已成为影响人类健康的最致命疾病之一。传统药物有明显的副作用，容易产生耐药性，而创新疗法价格昂贵，给患者带来很大的负担。尽管几十年的药物研究和发现已经产生了许多有用的化疗药物，但寻找具有增强疗效和安全性的新型化学实体仍在进行中。噻二唑可作为几种特定酶或信号通路的抑制剂。这些化合物经常与其他抗癌药物联合使用以提高其疗效。噻二唑与化疗或靶向治疗等其他抗癌治疗一起使用时，表现出有益的协同作用。它们对多种癌症细胞系显示出相当大的抗癌作用。该报告涵盖了从2021年到2024年的抗癌研究成果。本文综述了噻二唑类化合物及其类似物在抗癌方面的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊