Risk of myocardial infarction and Osteoporosis: Insights from the 2015–2018 NHANES and Mendelian randomization Studies

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2024-12-01 DOI:10.1016/j.ijcha.2024.101501

Guanmou Li , Bo Peng , Junqiao Fan , Dongqun Lin , Kunyang He , Rongjun Zou , Xiaoping Fan

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引用次数: 0

Abstract

Background

There are some common pathophysiological risk factors between myocardial infarction and osteoporosis, and the exact relationship between the two is not yet clear. Our study aims to provide evidence on the relationship between myocardial infarction and osteoporosis through the analysis of data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis from 2015 to 2018.

Methods

A two-sample MR study using summary statistics from genome-wide association studies (GWAS) was conducted to determine the causal relationship between myocardial infarction and osteoporosis. The Inverse Variance Weighted (IVW) method and other supplementary MR methods were used to validate the causal relationship between myocardial infarction and osteoporosis. Sensitivity analysis was performed to verify the robustness of the results. Weighted multivariable adjusted logistic regression was used on the NHANES 2015–2018 data to evaluate the relationship between HDL, LDL, and BMD factors closely related to myocardial infarction.

Results

An observational study conducted in NHANES included a total of 2516 participants. Weighted multivariable adjusted logistic regression analysis showed that HDL was positively correlated with BMD, with OR and 95 % CI of 0.051 and 0.013–0.088, respectively. LDL was negatively correlated with BMD. The MR analysis also indicated a causal relationship between myocardial infarction and osteoporosis (IVW (OR = 1.16, 95 % CI = 1.02–1.32, P = 0.03)). Sensitivity analysis further confirmed the robustness and reliability of these study results (all P > 0.05).

Conclusion

There is a causal relationship between myocardial infarction and osteoporosis.

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心肌梗死和骨质疏松的风险：来自2015-2018年NHANES和孟德尔随机化研究的见解

背景心肌梗死与骨质疏松之间存在一些共同的病理生理危险因素，两者之间的确切关系尚不清楚。我们的研究旨在通过分析2015 - 2018年国家健康与营养调查（NHANES）和孟德尔随机化（MR）分析的数据，为心肌梗死与骨质疏松症之间的关系提供证据。方法采用全基因组关联研究（GWAS）的汇总统计数据进行两样本MR研究，以确定心肌梗死与骨质疏松症之间的因果关系。采用逆方差加权（IVW）方法及其他辅助MR方法验证心肌梗死与骨质疏松之间的因果关系。进行敏感性分析以验证结果的稳健性。采用加权多变量调整logistic回归分析NHANES 2015-2018数据，评价与心肌梗死密切相关的HDL、LDL和BMD因素之间的关系。结果在NHANES中进行的一项观察性研究共纳入2516名参与者。加权多变量校正logistic回归分析显示HDL与BMD呈正相关，OR为0.051,95% CI为0.013 ~ 0.088。LDL与BMD呈负相关。MR分析还显示心肌梗死与骨质疏松之间存在因果关系（IVW (OR = 1.16, 95% CI = 1.02-1.32, P = 0.03)）。敏感性分析进一步证实了这些研究结果的稳健性和可靠性(所有P >；0.05)。结论心肌梗死与骨质疏松有一定的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.