New diketopiperazine dimers and 4-hydroxyphenylacetates from an endolichenic fungus Aspergillus sp.

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-11-27 DOI:10.1016/j.fitote.2024.106318

Bingjie Su , Tao Zhang , Mengjia Mao , Renzhong Wang , Baoqing You , Jing Zhang , Liyan Yu , Shuyi Si , Jingshuai Wu , Minghua Chen

引用次数: 0

Abstract

Two novel diketopiperazine dimers (1 and 2) and two new 4-hydroxyphenylacetates (5 and 6), along with two previously known diketopiperazine dimers were isolated from the culture of the endolichenic fungus Aspergillus sp. CPCC 400810. Their structures were determined through comprehensive spectroscopic analysis, including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) data. The absolute configurations of the new compounds were confirmed using Marfey's method and chemical synthesis.

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内生真菌曲霉的新二酮哌嗪二聚体和4-羟基苯乙酸酯。

从内生真菌Aspergillus sp. CPCC 400810中分离出两种新的二酮哌嗪二聚体（1和2）和两种新的4-羟基苯基乙酸酯（5和6），以及两种已知的二酮哌嗪二聚体。通过综合光谱分析，包括高分辨率电喷雾电离质谱（hremsims）和1D和2D核磁共振（NMR）数据，确定了它们的结构。用Marfey的方法和化学合成法确定了新化合物的绝对构型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.