Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-11-01 DOI:10.1016/j.mencom.2024.10.037

Anna M. Inshakova , Vasiliy A. Shchelkonogov , Natalya S. Shastina , Andrey V. Chekanov , Olga A. Baranova , Margarita O. Sokolova , Anastasia K. Ivanova , Anatoly I. Fedin , Ella Yu. Solov’eva

引用次数: 0

Abstract

To increase the therapeutic effectiveness of antioxidants (lipoic acid and glutathione) and improve their transport to target cells, various methods of modifying its substances are used. In this work, the synthesis of an amide derivative of lipoic acid and glutathione (GSH–LA) is performed, and GSH–LA nanodispersions based on Pluronic F68 are obtained. The most pronounced antioxidant and antiplatelet effects are exhibited by nanoparticles containing GSH–LA at the maximum tested concentration.

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谷胱甘肽-硫辛酸缀合物纳米分散体的抗氧化和抗血小板作用

为了提高抗氧化剂（硫辛酸和谷胱甘肽）的治疗效果并改善其向靶细胞的运输，使用了各种方法来修饰其物质。本文合成了硫辛酸和谷胱甘肽（GSH-LA）酰胺衍生物，并获得了基于Pluronic F68的GSH-LA纳米分散体。在最大测试浓度下，含有GSH-LA的纳米颗粒表现出最明显的抗氧化和抗血小板作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.