Synthesis, physicochemical properties and in vitro cytotoxic activity of aziridine-containing derivatives of 1,3,5-triazine

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-11-01 DOI:10.1016/j.mencom.2024.10.028

Olga V. Mikolaichuk , Alexandra V. Protas , Elena A. Popova , Olga S. Shemchuk , Mikhail D. Luttsev , Daler R. Dadadzhanov , Tigran A. Vartanyan , Andrey V. Petrov , Vladimir V. Sharoyko , Konstantin N. Semenov , Oleg E. Molchanov , Dmitrii N. Maistrenko

引用次数: 0

Abstract

6-{[4-(Aziridin-1-yl)-6-chloro-1,3,5-triazin-2-yl]amino}-hexanoic acid methyl ester and sodium salt were synthesized from cyanuric chloride. The sodium salt would interact with free radicals of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and inhibit hemolysis induced by Radachlorin. Both compounds interact with DNA with K_bin values of 1.09 × 10⁷ and 0.99 × 10⁷ dm³ mol⁻¹, respectively; they also demonstrate cytotoxic activity against human cancer cell lines.

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1,3,5-三嗪含氮吡啶衍生物的合成、理化性质及体外细胞毒活性

以三氯氰尿酸为原料合成了6-{[4-（亚氮啶-1-基）-6-氯-1,3,5-三嗪-2-基]氨基}-己酸甲酯和钠盐。钠盐可与2,2-二苯基-1-吡啶酰肼（DPPH）自由基相互作用，抑制Radachlorin诱导的溶血。两种化合物与DNA相互作用的Kbin值分别为1.09 × 107和0.99 × 107 dm3 mol−1；它们还显示出对人类癌细胞系的细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.