Clinical Effect Analysis and Prognostic Factors of Photodynamic Therapy for Cervical Precancerous Lesions

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-11-28 DOI:10.1002/jbio.202400454

Hong Zhu, Xiangrui Guo, Xu Li, Mengran Chang, Zhongyin Zhang, Junjun Dai

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引用次数: 0

Abstract

Objective

To evaluate the therapeutic effect of photodynamic therapy (PDT) on cervical precancerous lesions and prognostic factors.

Methods

173 patients diagnosed with cervical precancerous lesions and treated with PDT were included. Univariate analysis was performed on human papillomavirus (HPV) infection, patient age, number of treatments and number of medications before and after treatment, to evaluate the efficacy, adverse reactions and patient satisfaction.

Results

112 patients (64.5%) showed HPV clearance afrer PDT. Age ≥ 40 years was positively correlated with poor prognosis and number of treatments ≥ 6 was negatively correlated with poor prognosis. The satisfaction rate reached 94.79%, with 6 patients experiencing tolerable pain and no treatment discontinuations due to adverse reactions.

Conclusion

PDT is effective and safe for treating cervical precancerous lesions, with patient age and treatment frequency impacting outcomes. High patient satisfaction and tolerable adverse reactions support the application of PDT in clinical practice.

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光动力疗法治疗宫颈癌前病变的临床效果分析和预后因素

目的：评估光动力疗法（PDT）对宫颈癌前病变的治疗效果及预后因素：评估光动力疗法（PDT）对宫颈癌前病变的治疗效果及预后因素。对人类乳头瘤病毒（HPV）感染、患者年龄、治疗次数和治疗前后用药次数进行单变量分析，以评估疗效、不良反应和患者满意度：112名患者（64.5%）在PDT治疗后清除了HPV。年龄≥40岁与预后不良呈正相关，治疗次数≥6次与预后不良呈负相关。满意率达到 94.79%，6 名患者的疼痛可以忍受，没有因不良反应而中断治疗：结论：光动力疗法治疗宫颈癌前病变有效且安全，但患者年龄和治疗频率会影响治疗效果。患者的高满意度和可耐受的不良反应支持了光动力疗法在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.