Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons.

IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Colleen F Kelley, Maribel Acevedo-Quiñones, Allison L Agwu, Anchalee Avihingsanon, Paul Benson, Jill Blumenthal, Cynthia Brinson, Carlos Brites, Pedro Cahn, Valeria D Cantos, Jesse Clark, Meredith Clement, Cathy Creticos, Gordon Crofoot, Ricardo S Diaz, Susanne Doblecki-Lewis, Jorge A Gallardo-Cartagena, Aditya Gaur, Beatriz Grinsztejn, Shawn Hassler, Juan Carlos Hinojosa, Theo Hodge, Richard Kaplan, Marcus Lacerda, Anthony LaMarca, Marcelo H Losso, José Valdez Madruga, Kenneth H Mayer, Anthony Mills, Karam Mounzer, Nkosiphile Ndlovu, Richard M Novak, Alma Perez Rios, Nittaya Phanuphak, Moti Ramgopal, Peter J Ruane, Jorge Sánchez, Breno Santos, Patric Schine, Tanya Schreibman, LaShonda Y Spencer, Olivia T Van Gerwen, Ricardo Vasconcelos, Jose Gabriel Vasquez, Zwelethu Zwane, Stephanie Cox, Chris Deaton, Ramin Ebrahimi, Pamela Wong, Renu Singh, Lillian B Brown, Christoph C Carter, Moupali Das, Jared M Baeten, Onyema Ogbuagu
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引用次数: 0

Abstract

Background: Twice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy of lenacapavir for preexposure prophylaxis (PrEP) in cisgender men, transgender women, transgender men, and gender-nonbinary persons is unclear.

Methods: In this phase 3, double-blind, randomized, active-controlled trial, we randomly assigned participants in a 2:1 ratio to receive subcutaneous lenacapavir every 26 weeks or daily oral emtricitabine-tenofovir disoproxil fumarate (F/TDF). The primary efficacy analysis compared the incidence of HIV infection in the lenacapavir group with the background HIV incidence in the screened population. The secondary efficacy analysis compared the incidence of HIV infection in the lenacapavir group with that in the F/TDF group.

Results: Among 3265 participants who were included in the modified intention-to-treat analysis, HIV infections occurred in 2 participants in the lenacapavir group (0.10 per 100 person-years; 95% confidence interval [CI], 0.01 to 0.37) and in 9 participants in the F/TDF group (0.93 per 100 person-years; 95% CI, 0.43 to 1.77). The background HIV incidence in the screened population (4634 participants) was 2.37 per 100 person-years (95% CI, 1.65 to 3.42). The incidence of HIV infection in the lenacapavir group was significantly lower than both the background incidence (incidence rate ratio, 0.04; 95% CI, 0.01 to 0.18; P<0.001) and the incidence in the F/TDF group (incidence rate ratio, 0.11; 95% CI, 0.02 to 0.51; P = 0.002). No safety concerns were identified. A total of 26 of 2183 participants (1.2%) in the lenacapavir group and 3 of 1088 (0.3%) in the F/TDF group discontinued the trial regimen because of injection-site reactions.

Conclusions: The HIV incidence with twice-yearly lenacapavir was significantly lower than the background incidence and the incidence with F/TDF. (Funded by Gilead Sciences; PURPOSE 2 ClinicalTrials.gov number, NCT04925752.).

在男性和不同性别人群中使用一年两次的来那卡韦预防艾滋病。
背景:研究表明,每年两次皮下注射来那卡韦可有效预防双性恋女性感染艾滋病毒。来那卡韦用于顺性别男性、变性女性、变性男性和性别非二元者的暴露前预防(PrEP)的疗效尚不明确:在这项3期双盲、随机、主动对照试验中,我们以2:1的比例随机分配参与者接受每26周一次的皮下注射来那卡韦或每日口服恩曲他滨-替诺福韦二吡呋酯(F/TDF)。主要疗效分析将来那卡韦组的HIV感染率与筛查人群的背景HIV感染率进行了比较。次要疗效分析比较了来那卡韦组与F/TDF组的HIV感染率:在纳入修改后意向治疗分析的3265名参与者中,来那卡韦组有2人感染HIV(每100人年0.10例;95%置信区间[CI],0.01~0.37),F/TDF组有9人感染HIV(每100人年0.93例;95%置信区间,0.43~1.77)。筛查人群(4634 名参与者)的背景 HIV 感染率为每百人年 2.37 例(95% CI,1.65 至 3.42)。来那卡韦组的HIV感染率明显低于背景感染率(感染率比为0.04;95% CI为0.01至0.18;PConclusions.PCR):一年两次来那卡韦治疗组的艾滋病发病率明显低于背景发病率和F/TDF治疗组。(由吉利德科学公司资助;PURPOSE 2 ClinicalTrials.gov 编号:NCT04925752)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
New England Journal of Medicine
New England Journal of Medicine 医学-医学:内科
CiteScore
145.40
自引率
0.60%
发文量
1839
审稿时长
1 months
期刊介绍: The New England Journal of Medicine (NEJM) stands as the foremost medical journal and website worldwide. With an impressive history spanning over two centuries, NEJM boasts a consistent publication of superb, peer-reviewed research and engaging clinical content. Our primary objective revolves around delivering high-caliber information and findings at the juncture of biomedical science and clinical practice. We strive to present this knowledge in formats that are not only comprehensible but also hold practical value, effectively influencing healthcare practices and ultimately enhancing patient outcomes.
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