Does atopic dermatitis increase the risk of inflammatory bowel disease? A meta-analysis of data from 61 million participants.

IF 2.5 4区医学 Q3 ALLERGY

International Archives of Allergy and Immunology Pub Date : 2024-11-27 DOI:10.1159/000542777

Mengjie Wan, Xiaoyang Yang

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引用次数: 0

Abstract

Background: This review aimed to examine if atopic dermatitis (AD) led to an increased risk of inflammatory bowel disease (IBD) by collating data from longitudinal studies.

Summary: Cohort and case-control studies examining the risk of IBD, Crohn's disease (CD), or ulcerative colitis (UC) due to exposure to AD were included in this review. Articles were searched on PubMed, CENTRAL, Embase, Scopus, and Web of Science electronic repositories up to 2nd October 2024. Eight retrospective cohort studies with 61,190,816 participants were included. The meta-analysis found that AD was a significant risk factor for IBD (OR: 1.37 95% CI: 1.31, 1.43). No statistical heterogeneity was noted. Pooled analysis showed that exposure to AD was a significant risk factor for both CD (OR: 1.51 95% CI: 1.31, 1.76) and UC (OR: 1.33 95% CI: 1.13, 1.56). Both meta-analyses had high inter-study heterogeneity with I2=83% and I2=89% respectively. Results remained significant on sensitivity analysis.

Key messages: Our study shows an association between AD and IBD. The association was persistent for both CD and UC. Given the small increase in risk of IBD in AD, its clinical relevance may be questionable.

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特应性皮炎会增加患炎症性肠病的风险吗？对 6100 万参与者数据的荟萃分析。

背景：本综述旨在通过整理纵向研究的数据，研究特应性皮炎（AD）是否会导致炎症性肠病（IBD）的发病风险增加。摘要：本综述纳入了研究因接触特应性皮炎而导致IBD、克罗恩病（CD）或溃疡性结肠炎（UC）发病风险的队列研究和病例对照研究。截至 2024 年 10 月 2 日，在 PubMed、CENTRAL、Embase、Scopus 和 Web of Science 电子资料库中检索了相关文章。八项回顾性队列研究共纳入了 61 190 816 名参与者。荟萃分析发现，AD是IBD的重要风险因素（OR：1.37 95% CI：1.31, 1.43）。未发现统计异质性。汇总分析显示，接触 AD 是 CD（OR：1.51 95% CI：1.31, 1.76）和 UC（OR：1.33 95% CI：1.13, 1.56）的重要风险因素。两项荟萃分析的研究间异质性都很高，I2=83%和I2=89%。敏感性分析的结果仍有意义：我们的研究表明，AD 与 IBD 之间存在关联。关键信息：我们的研究表明，AD 与 IBD 之间存在关联，这种关联在 CD 和 UC 中均持续存在。鉴于AD患者罹患IBD的风险增加较小，其临床相关性可能值得商榷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Allergy and Immunology 医学-过敏

CiteScore

5.60

自引率

3.60%

发文量

105

审稿时长

2 months

期刊介绍： ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.