Role of leukocyte-associated Ig-like receptor-1 in the pathogenesis of Kawasaki disease and coronary artery aneurysms

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2024-11-25 DOI:10.1016/j.imlet.2024.106948

Zhuo Chen , Anle Zeng , Penghui Yang , Jing Zhang , Dong Liu , Mengling Li , Fengchuan Jing , Qijian Yi

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引用次数: 0

Abstract

Objective

To elucidate the relationship between leukocyte-associated Ig-like receptor-1 (LAIR-1) and the pathogenesis of Kawasaki disease (KD) and coronary artery aneurysms(CAA).

Methods

The study cohort comprises children who were diagnosed with KD and were categorized into two groups: KD patients with CAA (KD-CAA) and KD without CAA (KD-NCAA), with healthy children serving as control group (HC). LAIR-1 on leukocytes was examined via flow cytometry, while serum LAIR-1 (sLAIR-1) was quantified using ELISA. IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IFN-α, IFN-γ and TNF-α were examined by Immunofluorescence assay.

Results

sLAIR-1 levels were elevated in the KD and KD-CAA groups compared with those in the HC and KD-NCAA groups (P < 0.05). sLAIR-1 exhibited an area under the curve value of 0.858 for predicting KD (P < 0.001) and 0.628 for predicting CAA (P = 0.055, borderline significance). LAIR-1 was increased on the neutrophils in KD group, whereas it was lower in KD-CAA than that in KD-NCAA, and decreased in KD after IVIG treatment. In contrast, LAIR-1 was reduced on CD4+ and CD8+ T lymphocyte in KD group, and increased in KD after IVIG treatment (all P < 0.05). LAIR-1 on neutrophils showed a positive correlation with IL-5, while on CD4+ T cells, it was negatively correlated with IL-2, IL-6, IL-10, IFN-γ, and IL-8. On CD8+ T cells, LAIR-1 was negatively correlated with IL-2 and IFN-γ.

Conclusion

sLAIR-1 may serve as a potential biomarker for KD and CAAs, while LAIR-1 might be implicated in KD pathogenesis and CAA.

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白细胞相关 Ig 样受体-1 在川崎病和冠状动脉瘤发病机制中的作用

目的阐明白细胞相关 Ig 样受体-1（LAIR-1）与川崎病（KD）和冠状动脉瘤（CAA）发病机制的关系：研究对象包括确诊为KD的儿童，分为两组：方法：研究对象包括确诊为 KD 的儿童，分为两组：伴有 CAA 的 KD 患者（KD-CAA）和不伴有 CAA 的 KD 患者（KD-NCAA），健康儿童为对照组（HC）。白细胞上的 LAIR-1 通过流式细胞术进行检测，血清 LAIR-1 （sLAIR-1）通过 ELISA 进行定量。结果：与 HC 组和 KD-NCAA 组相比，KD 组和 KD-CAA 组的 sLAIR-1 水平升高（P < 0.sLAIR-1 预测 KD 的曲线下面积值为 1（P < 0.001），预测 CAA 的曲线下面积值为 1（P = 0.055，边缘显著性）。KD组中性粒细胞的LAIR-1增高，而KD-CAA组的LAIR-1低于KD-NCAA组，KD组在接受IVIG治疗后LAIR-1降低。相反，KD组CD4+和CD8+T淋巴细胞上的LAIR-1减少，而KD组经IVIG治疗后LAIR-1增加（均P＜0.05）。中性粒细胞上的 LAIR-1 与 IL-5 呈正相关，而 CD4+ T 细胞上的 LAIR-1 与 IL-2、IL-6、IL-10、IFN-γ 和 IL-8 呈负相关。结论：sLAIR-1可作为KD和CAA的潜在生物标记物，而LAIR-1可能与KD发病机制和CAA有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.