Safety and effectiveness of seahorse extract (Hippocampus comes L.) on the hematological profile and body weight of male rats induced by depo medroxyprogesterone acetate.

IF 1.5 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Advanced Veterinary and Animal Research Pub Date : 2024-09-29 eCollection Date: 2024-09-01 DOI:10.5455/javar.2024.k822

Trisnawati Mundijo, Franciscus Dhyanagiri Suyatna, Agung Eru Wibowo, Yusra Yusra, Yurnadi Hanafi Midoen

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引用次数: 0

Abstract

Objective: The objective of this study was to investigate the effectiveness and safety of seahorse (Hippocampus comes L.) extract on hematological profile and body weight on rats induced by depo medroxyprogesterone acetate (DMPA).

Materials and methods: Thirty adult male Sprague-Dawley rats with 200-250 gm and 8 weeks old. All rats were intramuscularly administered 1.25 mg/kg BW DMPA Merck Depo Geston at 150 mg/3 ml. The animals were divided into five main groups (6 each), consisting of aquadest (G1), CMC 1% (G2), seahorse extract (SE) dose 150 mg/kg BW (G3), 225 mg/kg BW (G4), and 300 mg/kg BW (G5). All rats were weighed until the end of the treatment week.

Results: The hematological profile and body weight of the group given SE tended to increase compared to the group not given extract; however, our hematological profile and body weight were in the normal range for rats.

Conclusion: We find that SE enhances the effectiveness of the hematological profile, body weight, and safety of rats induced by DMPA.

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海马提取物（Hippocampus comes L.）对醋酸甲羟孕酮诱导的雄性大鼠血液学特征和体重的安全性和有效性。

研究目的本研究旨在探讨海马（Hippocampus comes L.）提取物对醋酸甲羟孕酮（DMPA）诱导的大鼠血液学特征和体重的有效性和安全性：30 只成年雄性 Sprague-Dawley 大鼠，体重 200-250 克，8 周大。所有大鼠均肌肉注射 1.25 毫克/千克体重的 DMPA Merck Depo Geston，剂量为 150 毫克/3 毫升。动物被分为五大组（每组 6 只），分别为 aquadest 组（G1）、1% CMC 组（G2）、海马提取物组（SE），剂量分别为 150 毫克/千克体重组（G3）、225 毫克/千克体重组（G4）和 300 毫克/千克体重组（G5）。所有大鼠均称重至治疗周结束：结果：与未施用萃取物的组别相比，施用 SE 的组别血液学特征和体重都有增加的趋势；但是，我们的血液学特征和体重都在大鼠的正常范围内：我们发现，SE 能有效改善 DMPA 诱导的大鼠的血液特征、体重和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Advanced Veterinary and Animal Research Veterinary-Veterinary (all)

CiteScore

2.70

自引率

7.10%

发文量

审稿时长

6 weeks

期刊介绍： Journal of Advanced Veterinary and Animal Research (JAVAR) - is an open access, international, peer-reviewed, quarterly, highly-indexed scientific journal publishing original research findings and reviews on all aspects of veterinary and animal sciences. Basic and applied researches on- - Anatomy & histology - Animal health economics - Animal nutrition - Animal reproduction - Animal science - Antimicrobial resistance (AMR) - Biochemistry - Biotechnology - Dairy science - Epidemiology - Food hygiene and technology - Genetics and breeding - Immunology - Microbiology - Parasitology - Pathology - Pharmacology & toxicology - Physiology - Poultry science - Preventive veterinary medicine - Public health - Surgery & obstetrics - Veterinary extension studies - Wildlife & aquatic medicine - Zoo animal medicine.