Bioactive phenolics from the bulbs of Hymenocallis littoralis

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-11-26 DOI:10.1016/j.fitote.2024.106309

Ruyang Guan , Wenxin Zhang , Ziqi Deng , Jingwen Xu , Hui Hu , Ying Li , Xiangjiu He , Yihai Wang

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Abstract

Hymenocallis littoralis, commonly known as Coastal Spider lily, is a perennial herbaceous plant in the Amaryllidaceae family. It is native to tropical and subtropical regions of the Americas, celebrated for its remarkably beautiful flowers. In this study, five previously undescribed chromones, one new benzopyran, along with five known chromones and fourteen known flavonoids, were identified. Among these, compounds 6, 9, 12, 18, 19, 20, and 22 were natural products isolated from H. littoralis for the first time. Their structures were determined using spectroscopic techniques (NMR and MS). Anti-inflammatory activities of the isolated chromone and benzopyran were evaluated in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophage cells. Compound 11 exhibited significant inhibitory effects on nitric oxide (NO) production with an IC₅₀ value of 38.24 μM. Further investigations revealed that compound 11 exerted its anti-inflammatory activity by preventing the nuclear translocation of NF-κB and down-regulating the expression of pro-inflammatory factors, including iNOS, COX-2, IL-1β, and IL-6, in a concentration-dependent manner. This study provides evidence that benzopyran from H. littoralis may serve as a potential source of an anti-inflammatory agent.

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鳞茎中的生物活性酚。

海岸蛛丝百合（Hymenocallis littoralis）俗称 "海岸蛛丝百合"，是一种多年生草本植物，属于天南星科（Amaryllidaceae）。它原产于美洲的热带和亚热带地区，以其美丽的花朵而闻名。在这项研究中，发现了五种以前未曾描述过的色酮、一种新的苯并吡喃，以及五种已知的色酮和十四种已知的黄酮类化合物。其中，化合物 6、9、12、18、19、20 和 22 是首次从 H. littoralis 分离出来的天然产物。利用光谱技术（核磁共振和质谱）确定了它们的结构。在脂多糖（LPS）刺激的 RAW 264.7 巨噬细胞中评估了分离出的铬酮和苯并吡喃的抗炎活性。化合物 11 对一氧化氮（NO）的产生有明显的抑制作用，IC50 值为 38.24 μM。进一步研究发现，化合物 11 通过阻止 NF-κB 的核转位和下调 iNOS、COX-2、IL-1β 和 IL-6 等促炎因子的表达，以浓度依赖性的方式发挥其抗炎活性。本研究提供的证据表明，来自滨海草的苯并吡喃可能是一种潜在的抗炎剂来源。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.