Differential Characteristics on TCR Embedding Landscape Among Immune Checkpoint Blockade Responders Versus Non-Responders Against Non-Small Cell Lung Carcinoma.

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2024-11-27 DOI:10.1002/eji.202451374

Peiling Tsou, Chang-Jiun Wu

引用次数: 0

Abstract

For each patient in the NSCLC cohort, TCR sequences were converted into numerical vectors using the TCR2Vec model and projected onto a 2D landscape. The aggregated fractions of anti-LAA TEGs per patient were calculated. ICB responders had over-represented anti-LAA TEGs compared to non-responders.

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免疫检查点阻断剂治疗非小细胞肺癌的应答者与非应答者在 TCR 嵌入景观上的差异特征

使用 TCR2Vec 模型将 NSCLC 队列中每位患者的 TCR 序列转换成数字向量，并投影到二维图谱上。计算出每名患者抗LAA TEG的总比例。与非应答者相比，ICB应答者的抗LAA TEG比例过高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.