Remote Alkynylation of Aliphatic Amines.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-13 Epub Date: 2024-11-27 DOI:10.1021/acs.orglett.4c03468

Elizabeth M Dauncey, Tom D Sheppard, Peter D Smith, Rachel H Munday

引用次数: 0

Abstract

Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.

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脂肪胺的远程炔化。

过渡金属催化的 C-H 活化/官能化级联技术的进步大大扩展了合成化学家的工具箱。尽管如此，线性脂肪族胺的远程炔化协议仍然有限。本文公开了一种钯催化脂肪族胺炔化的定向基方法。通过克级反应和官能团相容性测试证明了该合成方法的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.