How proteins sense their cellular environment

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2024-11-28 DOI:10.1038/s41580-024-00812-1

Monika Fuxreiter

引用次数: 0

Abstract

The cellular environment is critical to protein function. How is information from many cellular components decoded in order to fine-tune biological activity? New models of biomolecular recognition raise the possibility that proteins engage in specific, yet fuzzy, interactions with their functional partners, which can provide a readout mechanism of the cellular context. Manipulating the cellular context to control protein function offers new therapeutic opportunities. In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing cellular environments.

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蛋白质如何感知细胞环境

细胞环境对蛋白质功能至关重要。如何对来自许多细胞成分的信息进行解码，以便对生物活性进行微调？生物分子识别的新模型提出了一种可能性，即蛋白质与其功能伙伴进行特定但模糊的相互作用，从而提供细胞环境的读出机制。操纵细胞环境来控制蛋白质功能提供了新的治疗机会。在这篇评论文章中，Monika Fuxreiter 讨论了动态模糊蛋白质相互作用的可能作用及其在不断变化的细胞环境中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.