Platelet-rich plasma treatment for chronic wounds: A case report and literature review.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2024-11-26 DOI:10.12998/wjcc.v12.i33.6635

Ana Dimova, Martin Boroš, Stefan Dimov, Janja Konjevod, Maja Svetec

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Abstract

Background: Wound healing is a complicated process that can be heavily influenced by patient comorbidities, in some cases leading to a chronic non-healing wound. Evidence presented in the medical literature supporting the clinical use of autologous platelet-rich plasma (PRP) in treatment of such wounds is becoming increasingly compelling. Mechanisms involved include complex interactions between the patient's thrombocytes, cytokines, and growth factors.

Case summary: We present a case of a 72-year-old male patient with a long-standing chronic wound and multiple comorbidities. Over the course of more than 7 months, the patient was unsuccessfully treated with all routinely used measures, including different dressing approaches. Multiple antibiotic regimens were administered for wound infection, with repeated evaluation of microbiological swab results. Finally, after three PRP applications, the wound showed clinical improvement with complete restitution of the epithelial layer of the skin.

Conclusion: PRP treatment may be beneficial to reduce healing time in chronic wounds.

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富血小板血浆治疗慢性伤口：病例报告和文献综述。

背景：伤口愈合是一个复杂的过程，会受到患者合并症的严重影响，在某些情况下会导致伤口长期不愈合。医学文献中支持临床使用自体富血小板血浆（PRP）治疗此类伤口的证据越来越令人信服。其中涉及的机制包括患者血小板、细胞因子和生长因子之间复杂的相互作用。病例摘要：我们介绍了一例 72 岁的男性患者，他患有长期慢性伤口和多种并发症。在长达 7 个多月的时间里，患者接受了各种常规治疗，包括不同的包扎方法，但均未奏效。为了治疗伤口感染，他使用了多种抗生素，并对微生物拭子结果进行了反复评估。最后，在使用了三次 PRP 后，伤口出现了临床改善，皮肤上皮层完全恢复：结论：PRP 治疗可缩短慢性伤口的愈合时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.