Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures.

IF 5.2 3区医学 Q1 IMMUNOLOGY

Vaccines Pub Date : 2024-11-19 DOI:10.3390/vaccines12111289

Li Chen, Chengwei Shao, Jingxin Li, Fengcai Zhu

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引用次数: 0

Abstract

The biological progression of aging encompasses complex physiological processes. As individuals grow older, their physiological functions gradually decline, including compromised immune responses, leading to immunosenescence. Immunosenescence significantly elevates disease susceptibility and severity in older populations while concurrently compromising vaccine-induced immune responses. This comprehensive review aims to elucidate the implications of immunosenescence for vaccine-induced immunity and facilitate the development of optimized vaccination strategies for geriatric populations, with specific focus on COVID-19, influenza, pneumococcal, herpes zoster, and respiratory syncytial virus (RSV) vaccines. This review further elucidates the relationship between immunosenescence and vaccine-induced immunity. This review presents a systematic evaluation of intervention strategies designed to enhance vaccine responses in older populations, encompassing adjuvant utilization, antigen doses, vaccination frequency modification, inflammatory response modulation, and lifestyle interventions, including physical activity and nutritional modifications. These strategies are explored for their potential to improve current vaccine efficacy and inform the development of next-generation vaccines for geriatric populations.

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免疫衰老对疫苗免疫反应和对策的影响。

衰老的生物学进程包含复杂的生理过程。随着年龄的增长，人的生理功能会逐渐衰退，包括免疫反应受损，从而导致免疫衰老。免疫衰老大大提高了老年人群对疾病的易感性和严重程度，同时也损害了疫苗诱导的免疫反应。本综述旨在阐明免疫衰老对疫苗诱导免疫的影响，并促进制定针对老年人群的优化疫苗接种策略，特别关注 COVID-19、流感、肺炎球菌、带状疱疹和呼吸道合胞病毒 (RSV) 疫苗。本综述进一步阐明了免疫衰老与疫苗诱导免疫之间的关系。本综述对旨在增强老年人群疫苗应答的干预策略进行了系统评估，包括佐剂使用、抗原剂量、疫苗接种频率调整、炎症反应调节和生活方式干预，包括体育锻炼和营养调整。研究探讨了这些策略在提高现有疫苗疗效方面的潜力，并为老年群体下一代疫苗的开发提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

8.90

自引率

16.70%

发文量

1853

审稿时长

18.06 days

期刊介绍： Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.