Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis.

IF 5.2 3区医学 Q1 IMMUNOLOGY

Vaccines Pub Date : 2024-11-20 DOI:10.3390/vaccines12111298

Zhicai Liu, Jing Wang, Zhaojun Lu, Yuyang Xu, Jian Du, Jiayin Han, Xuechao Zhang, Yan Liu

{"title":"Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis.","authors":"Zhicai Liu, Jing Wang, Zhaojun Lu, Yuyang Xu, Jian Du, Jiayin Han, Xuechao Zhang, Yan Liu","doi":"10.3390/vaccines12111298","DOIUrl":null,"url":null,"abstract":"Background: Immune thrombocytopenia (ITP) is an uncommon but serious adverse reaction after vaccination. However, its association with vaccines other than the measles-mumps-rubella vaccine remains debatable. This study aimed to analyze ITP cases following influenza vaccination and assess any potential association.Methods: We performed a systematic search of the Web of Science, Embase, and PubMed databases from their inception to 15 April 2024. Cases were characterized qualitatively, and relative risk was assessed using either fixed or random models.Results: A total of 24 studies were analyzed, including 16 patients from 14 case reports. Patients averaged 56.7 years old, half were female, and ten patients had a history of prior illness. The mean time between vaccination and diagnosis was 13.3 days. Treatment primarily involved corticosteroids or intravenous immunoglobulin, with most recovering within a month. The pooled odds ratio for ITP post-influenza vaccination was 0.94 (95%CI: 0.85-1.03). Subgroup analyses conducted according to the study design and vaccine type did not reveal any significant results.Conclusion: No evidence of an association between influenza vaccination and ITP was found. Further observational studies are required to verify this relationship.","PeriodicalId":23634,"journal":{"name":"Vaccines","volume":"12 11","pages":""},"PeriodicalIF":5.2000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599087/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccines","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/vaccines12111298","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Immune thrombocytopenia (ITP) is an uncommon but serious adverse reaction after vaccination. However, its association with vaccines other than the measles-mumps-rubella vaccine remains debatable. This study aimed to analyze ITP cases following influenza vaccination and assess any potential association.

Methods: We performed a systematic search of the Web of Science, Embase, and PubMed databases from their inception to 15 April 2024. Cases were characterized qualitatively, and relative risk was assessed using either fixed or random models.

Results: A total of 24 studies were analyzed, including 16 patients from 14 case reports. Patients averaged 56.7 years old, half were female, and ten patients had a history of prior illness. The mean time between vaccination and diagnosis was 13.3 days. Treatment primarily involved corticosteroids or intravenous immunoglobulin, with most recovering within a month. The pooled odds ratio for ITP post-influenza vaccination was 0.94 (95%CI: 0.85-1.03). Subgroup analyses conducted according to the study design and vaccine type did not reveal any significant results.

Conclusion: No evidence of an association between influenza vaccination and ITP was found. Further observational studies are required to verify this relationship.

查看原文本刊更多论文

流感疫苗与免疫性血小板减少症之间的关系：系统回顾与元分析》。

背景：免疫性血小板减少症（ITP免疫性血小板减少症（ITP）是接种疫苗后一种不常见但严重的不良反应。然而，除麻疹-流行性腮腺炎-风疹疫苗外，ITP与其他疫苗的关系仍有待商榷。本研究旨在分析接种流感疫苗后出现的 ITP 病例，并评估其潜在的关联性：方法：我们对 Web of Science、Embase 和 PubMed 数据库从开始到 2024 年 4 月 15 日的数据进行了系统检索。我们对病例进行了定性分析，并使用固定模型或随机模型评估了相对风险：结果：共分析了 24 项研究，包括 14 份病例报告中的 16 名患者。患者平均年龄为 56.7 岁，半数为女性，10 名患者有既往病史。从接种疫苗到确诊的平均时间为 13.3 天。治疗主要采用皮质类固醇或静脉注射免疫球蛋白，大多数患者在一个月内痊愈。接种流感疫苗后出现 ITP 的综合几率比为 0.94（95%CI：0.85-1.03）。根据研究设计和疫苗类型进行的分组分析未发现任何显著结果：结论：没有证据表明流感疫苗接种与ITP之间存在关联。结论：未发现流感疫苗接种与 ITP 之间存在关联的证据，需要进一步的观察研究来验证这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

8.90

自引率

16.70%

发文量

1853

审稿时长

18.06 days

期刊介绍： Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.