Dose-Response Relationship Between Serum 25(OH)D and the Risk of Abnormal Glycemic Status in Chinese Older Adults.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-10-26 DOI:10.3390/metabo14110579

Yuting Li, Jing Chen, Qingqing Man, Rui Wang, Deqian Mao, Min Li, Jian Zhang, Yichun Hu, Lichen Yang

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Abstract

Background/objectives: The relationship between serum 25-hydroxyvitaminD (25(OH)D) concentration and the risk of abnormal glycemic status remains contradictory. Whether sufficient 25(OH)D plays a role in reducing the risk of diabetes and prediabetes is debatable. Its dose-response relationship and the optimal 25(OH)D threshold are not clear. This study investigated the relationship between serum 25(OH)D and the risk of abnormal glycemic status to explore the optimal cut-off value.

Methods: This study included 5856 Chinese older adults aged 60 years and above from the China Adult Chronic Disease and Nutrition Survey (CACDNS 2015-2017). Serum 25(OH)D concentration was measured via an enzyme-linked immuosorbent assay. Abnormal glycemic status in the present study includes diabetes and prediabetes. Statistical methods such as a locally weighted regression and smoothing scatterplot (LOESS), restricted cubic spline regression (RCS) and binary and trend logistic regression were used to explore the dose-response relationship and the optimal 25(OH)D threshold.

Results: The concentration of 25(OH)D was nonlinearly related to the levels of FPG and HbA_1C in the LOESS curves. The nonlinear relation between 25(OH)D and the risk of diabetes and prediabetes was illustrated in the RCS curves and the optimal 25(OH)D threshold beneficial for diabetes was preliminarily explored to be 29.06 ng/mL, but no threshold for prediabetes was found. The dose-response results showed that for each 1 ng/mL increase in 25(OH)D, the risk of the fasting glucose type of diabetes reduced by 2.1%, the risk of the abnormal HbA_1C type of diabetes reduced by 2.2% and the risk of the mixed type of diabetes reduced by 1.7%, whereas a dose-response relationship was not found for prediabetes.

Conclusions: Higher serum 25(OH)D concentrations in Chinese older adults were associated with a reduced risk of glycemic abnormalities. The optimal 25(OH)D cut-off value was sufficiently beneficial if the diseased diabetes risk was 29.06 ng/mL, but no threshold was found for prediabetes.

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中国老年人血清 25(OH)D 与血糖异常风险之间的剂量-反应关系

背景/目的：血清 25- 羟基维生素 D (25(OH)D) 浓度与血糖异常风险之间的关系仍存在矛盾。充足的 25（OH）D 是否在降低糖尿病和糖尿病前期风险方面发挥作用还存在争议。其剂量-反应关系和 25（OH）D 的最佳阈值也不明确。本研究调查了血清 25（OH）D 与血糖异常风险之间的关系，以探索最佳临界值：本研究纳入了中国成人慢性病与营养调查（CACDNS 2015-2017）中的 5856 名 60 岁及以上的中国老年人。通过酶联免疫吸附法测定血清25（OH）D浓度。本研究中的异常血糖状态包括糖尿病和糖尿病前期。采用局部加权回归和平滑散点图（LOESS）、限制性三次样条回归（RCS）以及二元和趋势逻辑回归等统计方法来探讨剂量-反应关系和最佳 25(OH)D 阈值：结果：在LOESS曲线中，25（OH）D浓度与FPG和HbA1C水平呈非线性关系。RCS曲线显示了25（OH）D与糖尿病和糖尿病前期风险之间的非线性关系，初步探明对糖尿病有益的最佳25（OH）D阈值为29.06纳克/毫升，但未发现对糖尿病前期有益的阈值。剂量-反应结果显示，25（OH）D每增加1纳克/毫升，空腹血糖型糖尿病的风险降低2.1%，HbA1C异常型糖尿病的风险降低2.2%，混合型糖尿病的风险降低1.7%，而糖尿病前期没有发现剂量-反应关系：结论：中国老年人血清 25（OH）D 浓度越高，血糖异常风险越低。如果糖尿病患病风险为 29.06 纳克/毫升，25（OH）D 的最佳临界值就足够有益，但对于糖尿病前期则没有临界值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.