Evaluation of the In Vivo Skin Penetration of TXVector by Confocal Raman Spectroscopy.

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2024-11-27 DOI:10.1111/jocd.16696

Daniel Winn, Andrea Gilreath, David Pajuelo, Justyna M Meissner, Jose L Mullor

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引用次数: 0

Abstract

Background: Tranexamic acid (TXA) is a promising active to treat hyperpigmentation disorders, such as melasma and acne scars. However, TXA is highly hydrophilic and its penetration into the skin is poor and formulation dependent.

Aims: In this study, our aim was to evaluate the in vivo skin penetration of an ester-modified TXA, TXVector, directly on the skin of volunteers.

Methods: For the analysis of in vivo skin penetration of TXVector, we used in vivo confocal Raman spectroscopy (CRS). The use of CRS on live skin allows us to study directly how a compound affects skin composition at different depths and how this compound penetrates into the skin in real time.

Results: Our results showed that the TXA absorption into the skin via TXVector was 2.1-fold and 3.8-fold higher compared to free TXA 3% and TXA 1% formulations, respectively. Most importantly, upon application of TXVector, the TXA penetration flux into the skin was 107% and 280% higher than that of the free TXA 3% and TXA 1% formulations, respectively.

Conclusions: In summary, this study shows that the esterification-based TXVector formulation enhances the penetration flux of TXA and increases its bioavailability in the skin.

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通过共焦拉曼光谱评估 TXVector 的体内皮肤穿透性。

背景：氨甲环酸（TXA氨甲环酸（TXA）是一种治疗黄褐斑和痤疮疤痕等色素沉着疾病的有效药物。目的：在本研究中，我们的目的是评估一种酯改性 TXA（TXVector）直接在志愿者皮肤上的体内皮肤渗透性：为了分析 TXVector 在体内的皮肤渗透性，我们使用了体内共焦拉曼光谱（CRS）。通过在活体皮肤上使用共焦拉曼光谱，我们可以直接研究化合物如何影响不同深度的皮肤成分，以及该化合物如何实时渗透到皮肤中：我们的研究结果表明，通过 TXVector 进入皮肤的 TXA 吸收率分别是游离 TXA 3% 和 TXA 1% 制剂的 2.1 倍和 3.8 倍。最重要的是，使用 TXVector 后，皮肤对 TXA 的渗透通量分别比游离 TXA 3% 和 TXA 1% 制剂高 107% 和 280%：总之，本研究表明，基于酯化的 TXVector 制剂可增强 TXA 的渗透通量，提高其在皮肤中的生物利用度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.