Antibacterial and Antitumor Activities of Synthesized Sarumine Derivatives.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2024-11-19 DOI:10.3390/ijms252212412

Fangzhou Yang, Bin Jia, Hongli Wen, Xiufang Yang, Yangmin Ma

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引用次数: 0

Abstract

Our aim in this study was to explain the biological activity of the latest azafluoranthene. The natural product sarumine (12) and its derivatives (13-17) were synthesized and evaluated for their antibacterial and antitumor activities. The synthesis involved a simplified reaction pathway based on biaryl-sulfonamide-protected cyclization, and the compounds were characterized and studied using spectroscopic methods (¹HNMR and ¹³CNMR). Most of the compounds demonstrated improved antibacterial activity. Notably, sarumine demonstrated potent activity against S. aureus and B. subtilis, with an MIC of 8 μg/mL, showing comparable inhibitory effects to the positive control. Furthermore, molecular simulation studies indicated that sarumine exhibited significant binding affinity to FabH. The inhibitory effect of Cl was superior to the others on the structure, and the antitumor activity result also suggested that the inhibitory ability in PC-3 displayed by the R₁ derivatives of F and Cl substitutions was better than that of MDA-MB-231. These findings suggest that sarumine and its derivatives may represent new and promising candidates for further study.

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合成的沙鲁胺衍生物的抗菌和抗肿瘤活性。

本研究的目的是解释最新氮杂荧蒽的生物活性。我们合成了天然产物 sarumine (12) 及其衍生物 (13-17)，并评估了它们的抗菌和抗肿瘤活性。合成过程采用了基于双芳基磺酰胺保护环化的简化反应途径，并利用光谱方法（1HNMR 和 13CNMR）对化合物进行了表征和研究。大多数化合物的抗菌活性都有所提高。值得注意的是，沙鲁明对金黄色葡萄球菌和枯草杆菌具有强效活性，其 MIC 值为 8 μg/mL，抑制效果与阳性对照相当。此外，分子模拟研究表明，sarumine 与 FabH 具有显著的结合亲和力。而抗肿瘤活性结果也表明，F 和 Cl 取代的 R1 衍生物对 PC-3 的抑制能力优于 MDA-MB-231。这些研究结果表明，沙鲁明及其衍生物可能是有希望进一步研究的新候选化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).