Smart Nanocomposite Hydrogels as Next-Generation Therapeutic and Diagnostic Solutions.

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-10-24 DOI:10.3390/gels10110689
Anna Valentino, Sorur Yazdanpanah, Raffaele Conte, Anna Calarco, Gianfranco Peluso
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引用次数: 0

Abstract

Stimuli-responsive nanocomposite gels combine the unique properties of hydrogels with those of nanoparticles, thus avoiding the suboptimal results of single components and creating versatile, multi-functional platforms for therapeutic and diagnostic applications. These hybrid materials are engineered to respond to various internal and external stimuli, such as temperature, pH, light, magnetic fields, and enzymatic activity, allowing precise control over drug release, tissue regeneration, and biosensing. Their responsiveness to environmental cues permits personalized medicine approaches, providing dynamic control over therapeutic interventions and real-time diagnostic capabilities. This review explores recent advances in stimuli-responsive hybrid gels' synthesis and application, including drug delivery, tissue engineering, and diagnostics. Overall, these platforms have significant clinical potential, and future research is expected to lead to unique solutions to address unmet medical needs.

作为新一代治疗和诊断解决方案的智能纳米复合水凝胶。
刺激响应纳米复合凝胶结合了水凝胶和纳米粒子的独特性能,从而避免了单一成分的次优效果,为治疗和诊断应用创造了多功能的平台。这些混合材料可对温度、pH 值、光、磁场和酶活性等各种内部和外部刺激做出反应,从而实现对药物释放、组织再生和生物传感的精确控制。它们对环境线索的反应能力允许采用个性化医疗方法,提供对治疗干预的动态控制和实时诊断能力。本综述探讨了刺激响应型混合凝胶合成和应用的最新进展,包括药物输送、组织工程和诊断。总体而言,这些平台具有巨大的临床潜力,预计未来的研究将带来独特的解决方案,以满足尚未满足的医疗需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
期刊介绍: The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.
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