Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI:10.1080/17501911.2024.2430165

Anna-Maria D Zharova, Alexey D Perenkov, Maria V Vedunova

{"title":"Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging.","authors":"Anna-Maria D Zharova, Alexey D Perenkov, Maria V Vedunova","doi":"10.1080/17501911.2024.2430165","DOIUrl":null,"url":null,"abstract":"<p><p>Aging presents a significant challenge to health and social care systems due to the increasing proportion of the elderly population. The identification of reliable biomarkers to assess the progression of aging remains an unresolved question. Circular RNAs (circRNAs) are single-stranded covalently closed RNAs. They have been found to regulate various biological processes. CircRNAs are present in human biological fluids, are relatively stable, and accumulate with age, making them promising as biomarkers of aging. Current information on the expression of circRNAs in aging was analyzed using scientific databases. In this review, we have identified key stages in the study of circRNAs during aging and summarized the current understanding of their biogenesis. By focusing on the role of circRNAs in processes that contribute to aging - such as genomic stability, metabolism, cell death, and signaling pathways - we hypothesize that circRNAs may drive the aging process through their age-related accumulation and resultant deregulation. Examples of age-related differential expression of circRNAs in various species, including humans, are provided. This review highlights the importance of finding novel epigenetic biomarkers of aging, beyond the already identified molecules (circFOXO3, circRNA100783, circPVT1), and highlights circRNAs as a potential therapeutic target for the treatment of age-associated diseases.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"1465-1475"},"PeriodicalIF":3.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622801/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17501911.2024.2430165","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Aging presents a significant challenge to health and social care systems due to the increasing proportion of the elderly population. The identification of reliable biomarkers to assess the progression of aging remains an unresolved question. Circular RNAs (circRNAs) are single-stranded covalently closed RNAs. They have been found to regulate various biological processes. CircRNAs are present in human biological fluids, are relatively stable, and accumulate with age, making them promising as biomarkers of aging. Current information on the expression of circRNAs in aging was analyzed using scientific databases. In this review, we have identified key stages in the study of circRNAs during aging and summarized the current understanding of their biogenesis. By focusing on the role of circRNAs in processes that contribute to aging - such as genomic stability, metabolism, cell death, and signaling pathways - we hypothesize that circRNAs may drive the aging process through their age-related accumulation and resultant deregulation. Examples of age-related differential expression of circRNAs in various species, including humans, are provided. This review highlights the importance of finding novel epigenetic biomarkers of aging, beyond the already identified molecules (circFOXO3, circRNA100783, circPVT1), and highlights circRNAs as a potential therapeutic target for the treatment of age-associated diseases.

查看原文本刊更多论文

环状 RNA 是生命活动的多方面分子调节剂和衰老的潜在生物标志物。

由于老年人口比例不断增加，老龄化给医疗和社会护理系统带来了巨大挑战。确定可靠的生物标志物来评估衰老的进展仍然是一个悬而未决的问题。环状 RNA（circRNA）是单链共价封闭 RNA。研究发现，它们能调节各种生物过程。环状 RNA 存在于人体生物液体中，相对稳定，并随着年龄的增长而积累，因此很有希望成为衰老的生物标志物。我们利用科学数据库分析了目前有关衰老过程中 circRNAs 表达的信息。在这篇综述中，我们确定了研究衰老过程中 circRNAs 的关键阶段，并总结了目前对其生物发生的理解。通过重点研究 circRNA 在导致衰老的过程（如基因组稳定性、新陈代谢、细胞死亡和信号通路）中的作用，我们假设 circRNA 可能会通过与年龄相关的积累和由此导致的失调来驱动衰老过程。文中举例说明了包括人类在内的不同物种中与年龄相关的 circRNAs 表达差异。这篇综述强调了在已发现的分子（circFOXO3、circRNA100783、circPVT1）之外寻找新的衰老表观遗传生物标志物的重要性，并强调了circRNAs作为治疗老年相关疾病的潜在治疗靶点的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.