Paraquat-Induced Toxicities: Epidemiological Insights and Advances in Colorimetric and Fluorimetric Detection Methods.

Abstract

Paraquat (PQ) is a potent and widely utilized herbicide known for its effectiveness in controlling a broad spectrum of weeds. Its chemical properties make it an invaluable tool in agriculture, where it helps maintain crop yields and manage invasive plant species. However, despite its benefits in weed management, PQ poses significant risks due to its severe toxicity, which affects multiple organ systems in both humans and animals. The dual nature of PQ, as both a valuable agricultural chemical and a hazardous toxicant, necessitates a comprehensive understanding of its toxicological impacts and the development of effective detection and development strategies. This review aims to provide a comprehensive overview of PQ-induced toxicities, including neurotoxicity, lung toxicity, liver toxicity, kidney toxicity, and immunotoxicity. By synthesizing current knowledge on PQ health impacts, highlighting epidemiological trends, and exploring recent advancements in colorimetric and fluorimetric detection methods, this review seeks to contribute to the development of strategies for improving public health outcomes and enhancing our ability to manage the risks associated with PQ exposure. Addressing PQ toxicity through a multidisciplinary approach, incorporating toxicological, epidemiological, and technological perspectives, is essential for safeguarding health and promoting effective interventions.