Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Patients with Lipodystrophy Syndromes.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2024-11-19 DOI:10.3390/biom14111474
Michelle Krienke, Susan Kralisch, Leonie Wagner, Anke Tönjes, Konstanze Miehle
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Abstract

Serum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophies (LDs), severe cardio-metabolic complications can be observed. The dysregulation of several adipokines plays a significant role in the clinical manifestation of this syndrome. To date, there have been no studies of LRG1 levels in non-HIV-LD patients. We performed a cross-sectional analysis of LRG1 serum levels in 60 patients with non-HIV-associated LD and in 60 age-, sex-, and BMI-matched healthy controls. Furthermore, we investigated the gene expression of Lrg1 in a mouse model of generalised LD. No significant difference was found in the median concentration of LRG1 serum levels between LD patients (18.2 ng/L; interquartile range 8.3 ng/L) and healthy controls (17.8 ng/L; interquartile range 11.0 ng/L). LRG1 serum concentrations correlated positively with CRP serum levels (p < 0.001). Lrg1 mRNA expression was downregulated in the adipose tissue, whereas in the liver, no difference in Lrg1 expression between LD and wild-type mice was detected. In summary, circulating levels of LRG1 are associated with low-grade inflammation but cannot distinguish between patients with LD and controls.

脂肪营养不良综合征患者的血清富亮氨酸甲-2 糖蛋白 1 水平。
富亮氨酸α-2糖蛋白1(LRG1)的血清浓度在多种心血管代谢性疾病和炎症性疾病中都会升高。LRG1 在肝脏脂肪变性和胰岛素抵抗的发展过程中也起着重要作用。在脂肪变性疾病(LDs)中,可以观察到严重的心血管代谢并发症。几种脂肪因子的失调在这种综合征的临床表现中起着重要作用。迄今为止,还没有关于非艾滋病毒-LD 患者 LRG1 水平的研究。我们对 60 名非艾滋病毒相关性 LD 患者和 60 名年龄、性别和体重指数相匹配的健康对照者的血清 LRG1 水平进行了横断面分析。此外,我们还研究了全身性 LD 小鼠模型中 Lrg1 的基因表达。LD患者(18.2纳克/升;四分位数间距8.3纳克/升)和健康对照组(17.8纳克/升;四分位数间距11.0纳克/升)的LRG1血清浓度中位数没有明显差异。LRG1 血清浓度与 CRP 血清水平呈正相关(p < 0.001)。脂肪组织中的 Lrg1 mRNA 表达下调,而在肝脏中,LD 小鼠和野生型小鼠的 Lrg1 表达没有差异。总之,循环中的 LRG1 水平与低度炎症有关,但不能区分 LD 患者和对照组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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