The Notable Role of Telomere Length Maintenance in Complex Diseases.

IF 3.9 3区工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedicines Pub Date : 2024-11-15 DOI:10.3390/biomedicines12112611

Jiahui Lv, Xinmiao Zhao, Linjie Zhao, Chengjun Gong, Wanjie Zheng, Li Guo, Jun Wang, Tingming Liang

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Abstract

Telomere length function serves as a critical biomarker for biological aging and overall health. Its maintenance is linked to cancer, neurodegenerative conditions, and reproductive health. This review mainly examines genetic variations and environmental influences on telomere dynamics, highlighting key regulatory genes and mechanisms. Advances in telomere measurement methodologies are also reviewed, underscoring the importance of precise telomere assessment for disease prevention and treatment. Telomerase activation offers potential for cellular lifespan extension and anti-aging effects, whereas its inhibition emerges as a promising therapeutic approach for cancer. Regulatory mechanisms of tumor suppressor genes on telomerase activity are analyzed, with a comprehensive overview of the current state and future potential of telomerase inhibitors. In addition, the association between telomeres and neurodegenerative diseases is discussed, detailing how telomere attrition heightens disease risk and outlining multiple pathways by which telomerase protects neurons from damage and apoptosis.

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端粒长度维持在复杂疾病中的显著作用。

端粒长度功能是生物衰老和整体健康的重要生物标志。端粒的维持与癌症、神经退行性疾病和生殖健康有关。这篇综述主要研究了端粒动态的遗传变异和环境影响，突出了关键的调控基因和机制。此外还回顾了端粒测量方法的进展，强调了精确评估端粒对疾病预防和治疗的重要性。端粒酶的激活具有延长细胞寿命和抗衰老的潜力，而抑制端粒酶则是一种很有前景的癌症治疗方法。研究分析了肿瘤抑制基因对端粒酶活性的调控机制，并全面概述了端粒酶抑制剂的现状和未来潜力。此外，还讨论了端粒与神经退行性疾病之间的联系，详细介绍了端粒损耗如何增加疾病风险，并概述了端粒酶保护神经元免受损伤和凋亡的多种途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

5.20

自引率

8.50%

发文量

2823

审稿时长

8 weeks

期刊介绍： Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.