Heart Failure: A Deficiency of Energy-A Path Yet to Discover and Walk.

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ioannis Paraskevaidis, Christos Kourek, Dimitrios Farmakis, Elias Tsougos
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Abstract

Heart failure is a complex syndrome and our understanding and therapeutic approach relies mostly on its phenotypic presentation. Notably, the heart is characterized as the most energy-consuming organ, being both a producer and consumer, in order to satisfy multiple cardiac functions: ion exchange, electromechanical coordination, excitation-contraction coupling, etc. By obtaining further knowledge of the cardiac energy field, we can probably better characterize the basic pathophysiological events occurring in heart disease patients and understand the metabolic substance changes, the relationship between the alteration of energy production/consumption, and hence energetic deficiency not only in the heart as a whole but in every single cardiac territory, which will hopefully provide us with the opportunity to uncover the beginning of the heart failure process. In this respect, using (a) newer imaging techniques, (b) biomedicine, (c) nanotechnology, and (d) artificial intelligence, we can gain a deeper understanding of this complex syndrome. This, in turn, can lead to earlier and more effective therapeutic approaches, ultimately improving human health. To date, the scientific community has not given sufficient attention to the energetic starvation model. In our view, this review aims to encourage scientists and the medical community to conduct studies for a better understanding and treatment of this syndrome.

心力衰竭:能量不足--一条有待探索和行走的道路。
心力衰竭是一种复杂的综合征,我们对它的了解和治疗方法主要依赖于它的表型表现。值得注意的是,心脏是消耗能量最多的器官,既是能量的生产者,也是能量的消耗者,以满足多种心脏功能:离子交换、机电协调、兴奋-收缩耦合等。通过对心脏能量场的进一步了解,我们或许可以更好地描述心脏病患者发生的基本病理生理事件,了解代谢物质的变化、能量生产/消耗的改变之间的关系,从而了解不仅是整个心脏,而且是每一个心脏区域的能量缺乏,这将有望为我们提供机会,揭开心力衰竭过程的开端。在这方面,利用(a)较新的成像技术、(b)生物医学、(c)纳米技术和(d)人工智能,我们可以更深入地了解这种复杂的综合征。反过来,这又能让我们更早、更有效地找到治疗方法,最终改善人类健康。迄今为止,科学界尚未对能量饥饿模型给予足够的重视。我们认为,这篇综述旨在鼓励科学家和医学界开展研究,以便更好地理解和治疗这种综合征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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