Efficacy of dermapen combined with topical insulin versus dermapen combined with topical hyaluronic acid in treatment of stretch marks: comparative study

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2024-11-27 DOI:10.1007/s00403-024-03532-w

Manar Reda Yousef Ebrahim, Hanan Mohamed Ali Darwish, Sara Ahmed Galal

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Abstract

Striae distensae (SD) are visible linear scars developing in areas of dermal damage. Insulin is a peptide hormone that can potentially help restore the integrity of damaged skin and promote the reformation of granulation tissue. Hyaluronic Acid is commonly used in aesthetic medicine. To evaluate the clinical response and efficacy of microneedling and topical insulin against microneedling and topical hyaluronic acid in treating stretch marks. The study was conducted on 30 patients suffering from striae distensae in the abdomen. The patients were treated by microneedling followed by hyaluronic acid on the right side. The second group was treated by microneedling followed by topical insulin on the left side of the abdomen. At the end of the study the improvement with hyaluronic acid was 23.3% of patients with excellent improvement and 30.0% of patients with marked improvement. The improvement with topical insulin was 30.0% of patients with excellent improvement and 20.0% of patients with marked improvement. Microneedling followed by hyaluronic acid or topical insulin can be an effective and safe therapeutic option for the treatment of Stretch marks with no significant side effects.

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皮炎平联合外用胰岛素与皮炎平联合外用透明质酸治疗妊娠纹的疗效对比研究。

妊娠纹（SD）是在真皮损伤部位形成的明显线状疤痕。胰岛素是一种肽类激素，可帮助恢复受损皮肤的完整性，促进肉芽组织的重组。透明质酸常用于美容医学。目的：评估微针和外用胰岛素与微针和外用透明质酸治疗妊娠纹的临床反应和疗效。研究对象为 30 名腹部妊娠纹患者。第一组患者接受微针治疗，然后在右侧注射玻尿酸。第二组患者在腹部左侧进行微针治疗，然后使用局部胰岛素。研究结束时，23.3%的患者使用玻尿酸后病情得到了很好的改善，30.0%的患者病情得到了明显改善。使用局部胰岛素后，30.0%的患者病情得到了很好的改善，20.0%的患者病情得到了明显改善。微针注射后使用透明质酸或外用胰岛素治疗妊娠纹是一种有效而安全的治疗方法，且无明显副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.