Oxidative Stress in Canine Diseases: A Comprehensive Review.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-11-15 DOI:10.3390/antiox13111396

Perez-Montero Blanca, Fermín-Rodriguez María Luisa, Miró Guadalupe, Cruz-Lopez Fátima

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引用次数: 0

Abstract

Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lacking. This comprehensive review aims to summarize the existing literature on the role of OS in canine diseases, highlighting its potentially detrimental effect on various organs and systems. Some inconsistencies among studies exist, likely due to varying biomarkers and sample types. However, there is substantial evidence supporting the involvement of OS in the development or progression of numerous canine disorders, such as cardiovascular, oncologic, endocrine, gastrointestinal, hematologic, renal, neurologic, infectious, and parasitic diseases, among others. Additionally, this review discusses the efficacy of antioxidant and pro-oxidant therapeutic agents for these conditions. Dietary interventions to counteract OS in dogs have gained significant attention in recent years, although further research on the topic is needed. This review aims to serve as a foundational resource for future investigations in this promising field.

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犬病中的氧化应激：全面回顾。

氧化应激（Oxidative stress，OS）被定义为有利于氧化剂的氧化还原平衡的破坏，它已成为人类和兽医学中多种疾病的主要诱因。虽然已有多篇综述探讨了氧化应激在人类病理学中的影响，但还缺乏对犬科疾病的详尽综述。这篇综合综述旨在总结有关OS在犬科疾病中作用的现有文献，强调OS对各种器官和系统的潜在有害影响。由于生物标志物和样本类型不同，各研究之间存在一些不一致之处。不过，有大量证据证明 OS 与许多犬科疾病的发生或发展有关，如心血管、肿瘤、内分泌、胃肠道、血液、肾脏、神经、传染病和寄生虫病等。此外，本综述还讨论了抗氧化剂和促氧化剂对这些疾病的疗效。近年来，通过饮食干预来对抗狗体内的操作系统已引起了极大的关注，但这一主题还需要进一步的研究。本综述旨在为这一前景广阔的领域的未来研究提供基础资料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.