Trassanee Chatmethakul, Amy H Stanford, Danielle R Rios, Adrianne R Bischoff, Theresa Czech, Patrick J McNamara
{"title":"Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report.","authors":"Trassanee Chatmethakul, Amy H Stanford, Danielle R Rios, Adrianne R Bischoff, Theresa Czech, Patrick J McNamara","doi":"10.1055/a-2447-8662","DOIUrl":null,"url":null,"abstract":"<p><p>Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e270-e273"},"PeriodicalIF":0.8000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597592/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJP Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2447-8662","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide.
拉科酰胺（Vimpat Harris FRC Corporation，2022 UCB, Inc. Smyrna, GA 30080）是一种抗癫痫药物，通过阻断电压门控神经元钠通道发挥作用。根据成人和儿科数据推断，该药最近在新生儿中的应用表明其安全性良好。值得注意的是，早产儿具有独特的发育特征，可能会增加其发生不良反应的风险。我们介绍了一例早产新生儿在开始服用拉科酰胺时出现左心室功能障碍的病例。
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