Recent progress in synthesis, reactivity, and biological activities of selenopheno[2,3-c/3,2-c] pyrazole heterocycles

Abstract

Pyrazole and selenophene are valuable heterocyclic compounds that play a crucial role in the development of new drug molecules. Combining the selenophene and pyrazole moieties to hybrid structures has opened exciting possibilities for various pharmacological activities, leading to the discovery of selenophenopyrazoles, including selenopheno[2,3-c]pyrazole and selenopheno[3,2-c]pyrazole. All of which exhibit intriguing properties. The synthesis of selenophenopyrazoles can be accomplished through several chemical reactions: Vilsmeier–Haack reaction, Thorpe–Ziegler cyclization, and Suzuki cross-coupling.