Super response to liraglutide in people with obesity: A case report and literature review

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion Pub Date : 2024-08-23 DOI:10.1016/j.endinu.2024.05.014

Sonsoles Gutiérrez Medina , Elena Sánchez Campayo , Sonsoles Guadalix , Javier Escalada

引用次数: 0

Abstract

GLP1 receptor agonists (GLP1-RAs) are currently the most widely used pharmacological option to treat obesity. However, considerable heterogeneity in weight loss response has been observed with different anti-obesity drugs and response predictors to these drugs still remain ambiguous. Furthermore, very few published data have been available on cases of high-responders to treatment with GLP1-RAs. In this article, we present the case of a patient with grade 4 obesity (initial body mass index, 50.2 kg/m²) with associated mechanical and metabolic complications who achieved an initial weight loss of 40% at 1 year with hygienic-dietary measures and drug treatment with liraglutide. We also review the available literature on factors potentially contributing to variations in weight loss with GLP1-RAs in general and liraglutide, in particular.

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肥胖症患者对利拉鲁肽的超级反应：病例报告和文献综述

GLP1 受体激动剂（GLP1-RAs）是目前治疗肥胖症最广泛使用的药物。然而，不同的抗肥胖药物在减轻体重反应方面存在很大的异质性，而且这些药物的反应预测指标仍不明确。此外，关于 GLP1-RAs 治疗高反应者病例的公开数据也非常少。在这篇文章中，我们介绍了一位患有四级肥胖症（初始体重指数为 50.2 kg/m2）并伴有机械性和代谢性并发症的患者的病例，该患者在接受卫生饮食措施和利拉鲁肽药物治疗 1 年后，初始体重下降了 40%。我们还回顾了现有文献中可能导致 GLP1-RA（尤其是利拉鲁肽）减重变化的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinologia, Diabetes y Nutricion Nursing-Nutrition and Dietetics

CiteScore

2.10

自引率

0.00%

发文量

169

审稿时长

35 days

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.