Evaluation of the Electroconvulsive Therapy’s Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography

IF 5.3 1区医学 Q1 PSYCHIATRY

Schizophrenia Bulletin Pub Date : 2024-11-26 DOI:10.1093/schbul/sbae187

Faruk Kurhan, Veysi Yıldız, Gülsüm Zuhal Kamış, Kübra Karataş, Muhammed Batur

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Abstract

Background and Hypothesis Schizophrenia is a complex disorder thought to have neurodevelopmental and neurodegenerative aspects. Optical coherence tomography (OCT) measurements of schizophrenia patients revealed that the retinal layers of these patients were thinner than those of healthy controls. This study aimed to examine retinal changes in first-episode psychosis patients treated with electroconvulsive therapy (ECT) via OCT. Study Design Thirty first-episode psychosis patients (13 men, 17 women) aged 18 to 65 years who had no comorbidities and no smoking, alcohol, or substance use disorders and who were treated with ECT were included in the study. The patients were evaluated using OCT before treatment and after an average of 7.4 sessions of ECT in remission, and the results were compared. Study Results Statistically significant increases were observed in retinal layer thickness, inner plexiform layer, outer plexiform layer, and total retinal thickness within the 1 mm ring (P = .015, P = .045, and P = .025, respectively). The inner nuclear layer thickness significantly increased within the 6 mm ring (P = .037). Conclusions In conclusion, ECT noticeably affected retinal structures, particularly according to similar measurements, indicating potential improvements in and the ability to reverse neuronal degeneration after one month of treatment. This study highlights the potential impact of ECT on retinal structures in individuals experiencing first-episode psychosis, as it can enhance specific retinal layers and reverse neuronal degeneration.

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利用光学相干断层扫描评估电休克疗法对首发精神病患者视网膜结构的影响

背景与假设精神分裂症是一种复杂的疾病，被认为与神经发育和神经退行性病变有关。对精神分裂症患者进行的光学相干断层扫描（OCT）测量显示，这些患者的视网膜层比健康对照组的视网膜层薄。本研究旨在通过光学相干断层扫描检查接受电休克疗法（ECT）治疗的首发精神病患者的视网膜变化。研究设计研究纳入了 30 名首次发病的精神病患者（13 名男性，17 名女性），年龄在 18 岁至 65 岁之间，无合并症，无吸烟、酗酒或药物使用障碍，接受过 ECT 治疗。在治疗前和平均 7.4 次 ECT 缓解治疗后，使用 OCT 对患者进行评估，并对结果进行比较。研究结果观察到视网膜层厚度、内层丛状层、外层丛状层和 1 毫米环内视网膜总厚度均有统计学意义的增加（分别为 P = .015、P = .045 和 P = .025）。6 毫米环内的内核层厚度明显增加（P = .037）。结论总之，ECT 对视网膜结构产生了明显的影响，特别是根据类似的测量结果，这表明治疗一个月后，视网膜结构可能得到改善，并有能力逆转神经元变性。这项研究强调了电痉挛疗法对首发精神病患者视网膜结构的潜在影响，因为它可以增强特定视网膜层并逆转神经元变性。

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来源期刊

Schizophrenia Bulletin 医学-精神病学

CiteScore

11.40

自引率

6.10%

发文量

163

审稿时长

4-8 weeks

期刊介绍： Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.