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tRNA methylation drives early postnatal cardiomyocyte maturation

IF 9.4 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Nature cardiovascular research Pub Date : 2024-11-25 DOI:10.1038/s44161-024-00572-3
Pilar Ruiz-Lozano, Mark Mercola
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Abstract

The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.

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tRNA 甲基化驱动出生后早期心肌细胞成熟
出生后心肌细胞的成熟对于心脏在成年期维持泵活动至关重要。甲基转移酶METTL1通过促进生酮和脂肪酸氧化，在小鼠出生后的第一周内驱动心肌细胞成熟。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
Nature cardiovascular research
Nature cardiovascular research
CiteScore
5.70
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0.00%
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