How dopamine shapes trust beliefs

Abstract

Learning whom to trust is integral for healthy relationships and social cohesion, and atypicalities in trust learning are common across a range of clinical conditions, including schizophrenia spectrum disorders, Parkinson's disease, and depression. Persecutory delusions – rigid, unfounded beliefs that others are intending to harm oneself – significantly impact affected individuals' lives as they are associated with a range of negative health outcomes, including suicidal behaviour and relapse. Recent advances in computational modelling and psychopharmacology have significantly extended our understanding of the brain bases of dynamic trust learning, and the neuromodulator dopamine has been suggested to play a key role in this. However, the specifics of this role on a computational and neurobiological level remain to be fully established. The current review article provides a comprehensive summary of novel conceptual developments and empirical findings regarding the computational role of dopamine in social learning processes. Research findings strongly suggest a conceptual shift, from dopamine as a reward mechanism to a teaching signal indicating which information is relevant for learning, and shed light on the neurocomputational mechanisms via which antipsychotics may alleviate symptoms of aberrant social learning processes such as persecutory delusions. Knowledge gaps and inconsistencies in the extant literature are examined and the most pressing issues highlighted, laying the foundation for future research that will further advance our understanding of the neuromodulation of social belief updating processes.