Brief description of Mendelian randomized studies.

Abstract

Mendelian randomization (MR) offers a more rigorous framework than traditional observational studies by using genetic variants to assess causal relationships. Three critical assumptions are necessary for MR validity: relevance, independence, and exclusion restriction. These assumptions ensure that the genetic variants accurately reflect the risk factor's impact on the outcome. By elucidating these key points, this article aims to enhance understanding of MR's strengths and limitations in epidemiological research.