IMPACT OF NIRSEVIMAB ON RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN HOSPITALIZED INFANTS: A REAL-WORLD STUDY.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-11-26 DOI:10.1097/INF.0000000000004630

Eric Jeziorski, Antoine Ouziel, Marie Cotillon, Constance Bridonneau, Etienne Bizot, Clément Basse, Aurélie Portefaix, François Dubos, Stéphane Béchet, Lea Domitien, Carine Jaillet, Sorin Abrudan, Rolf Kramer, Vincent Gajdos, Elise Launay, Romain Basmaci, Yves Gillet, Robert Cohen, Corinne Levy

引用次数: 0

Abstract

Regarding nirsevimab immunization status, among 1085 infants hospitalized for bronchiolitis, the odds of hospitalization for respiratory syncytial virus bronchiolitis were 4.7 times higher for nonimmunized children. Immunized infants were less likely to require oxygen supplementation (20.2% vs. 30.6%, P = 0.02) and had a 1-day shorter hospital stay. Respiratory syncytial virus bronchiolitis was less frequent and less severe in infants immunized with nirsevimab.

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尼舍单抗对住院婴儿呼吸道合胞病毒支气管炎的影响：真实世界研究。

关于尼舍单抗的免疫状况，在因支气管炎住院的 1085 名婴儿中，未免疫儿童因呼吸道合胞病毒支气管炎住院的几率是未免疫儿童的 4.7 倍。免疫接种的婴儿需要补充氧气的几率较低（20.2% 对 30.6%，P = 0.02），住院时间也缩短了 1 天。接受过尼舍韦单抗免疫接种的婴儿患呼吸道合胞病毒支气管炎的几率较低，且病情较轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.