Ferroptosis-related prognostic model of mantle cell lymphoma.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI:10.1515/med-2024-1090

Qianwen Gao, Xin Wang, Yue Zhang, Jingjing Wen, Fangfang Wang, Zhimei Lin, Yu Feng, Jingcao Huang, Qian Li, Hongmei Luo, Xiang Liu, Xinyu Zhai, Linfeng Li, Siyao He, Ziyue Mi, Li Zhang, Ting Niu, Caigang Xu, Yuhuan Zheng

{"title":"Ferroptosis-related prognostic model of mantle cell lymphoma.","authors":"Qianwen Gao, Xin Wang, Yue Zhang, Jingjing Wen, Fangfang Wang, Zhimei Lin, Yu Feng, Jingcao Huang, Qian Li, Hongmei Luo, Xiang Liu, Xinyu Zhai, Linfeng Li, Siyao He, Ziyue Mi, Li Zhang, Ting Niu, Caigang Xu, Yuhuan Zheng","doi":"10.1515/med-2024-1090","DOIUrl":null,"url":null,"abstract":"Background: Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin's lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for prognostic evaluation of patients with MCL.Methods: Using the single-cell RNA sequencing datasets GSE184031 and mRNA sequencing data GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next a prognostic model was constructed by Cox regression and Least absolute selection and shrinkage Operator regression analysis. Finally, we used CIBERSORT to analyze the immune microenvironment and the \"oncoPredict\" package to predict potential drugs.Results: In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1, and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod, and Trametinib, were identified as potential therapeutic agents for patients with MCL.Conclusion: In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL. This study provides a prognostic model with ferroptosis-related gene signature for MCL. The results show that the model helps predict prognosis in MCL.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241090"},"PeriodicalIF":1.7000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587922/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2024-1090","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin's lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for prognostic evaluation of patients with MCL.

Methods: Using the single-cell RNA sequencing datasets GSE184031 and mRNA sequencing data GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next a prognostic model was constructed by Cox regression and Least absolute selection and shrinkage Operator regression analysis. Finally, we used CIBERSORT to analyze the immune microenvironment and the "oncoPredict" package to predict potential drugs.

Results: In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1, and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod, and Trametinib, were identified as potential therapeutic agents for patients with MCL.

Conclusion: In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL. This study provides a prognostic model with ferroptosis-related gene signature for MCL. The results show that the model helps predict prognosis in MCL.

查看原文本刊更多论文

套细胞淋巴瘤铁蛋白沉积相关预后模型

背景：套细胞淋巴瘤（MCL）是一种 B 细胞非霍奇金淋巴瘤：套细胞淋巴瘤（MCL）是一种B细胞非霍奇金淋巴瘤。铁依赖性程序性细胞死亡（Ferroptosis）与癌症预后密切相关。在这项研究中，我们建立了一个铁突变相关基因模型，用于评估MCL患者的预后：方法：利用基因表达总库（Gene Expression Omnibus）中的单细胞 RNA 测序数据集 GSE184031 和 mRNA 测序数据 GSE32018，我们发现了 139 个 MCL 中与铁沉降相关的基因。接下来，我们通过 Cox 回归和最小绝对选择及收缩操作者回归分析构建了预后模型。最后，我们使用CIBERSORT分析免疫微环境，并使用 "oncoPredict "软件包预测潜在药物：在我们的模型中，MCL患者的预后是通过7个基因ANXA1、IL1B、YBX1、CCND1、MS4A1、MFHAS1和RILPL2的风险评分来评估的。根据我们的模型，患者被分为高危和低危两组，高危患者的总生存率较低。最后，根据我们的模型和计算药物敏感性分析，BMS-754807、SB216763、Doramapimod和Trametinib这四种小分子化合物被确定为MCL患者的潜在治疗药物：总之，我们为MCL提供了一个具有铁蛋白沉积相关基因特征的预后模型。本研究为MCL提供了一个带有铁蛋白沉积相关基因特征的预后模型。结果表明，该模型有助于预测MCL的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.