Acupuncture therapy in autoimmune diseases: A narrative review

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2024-11-23 DOI:10.1016/j.autrev.2024.103709

Dorit Gamus , Yehuda Shoenfeld

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引用次数: 0

Abstract

We provide a narrative review of experimental and clinical evidence for the effect of acupuncture in autoimmune diseases, based on randomized controlled studies, systematic review and meta-analyses, published between the years 2000–2023.

Acupuncture in experimental models of rheumatoid arthritis (RA), multiple sclerosis, psoriasis, ulcerative colitis (UC) downregulated inflammatory cytokine expression, increased IL-10 expression, improved Treg cell differentiation, and also modulated macrophage polarization in RA and UC models. The anti-inflammatory effect of acupuncture in autoimmune disorders has been demonstrated to involve vagal-adrenal and cholinergic anti-inflammatory pathways. The analgesic effect of acupuncture involves both peripheral and central anti-nociceptive mechanisms.

Randomized controlled studies support the use of acupuncture in rheumatoid arthritis, fibromyalgia, Crohn's disease and in Sjogren's syndrome. Some evidence indicates that acupuncture may be beneficial as a symptomatic treatment for multiple sclerosis, myasthenia gravis, psoriasis and ankylosing spondylitis.

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针灸治疗自身免疫性疾病：综述。

我们基于 2000-2023 年间发表的随机对照研究、系统综述和荟萃分析，对针灸治疗自身免疫性疾病的实验和临床证据进行了叙述性综述。在类风湿性关节炎（RA）、多发性硬化症、银屑病、溃疡性结肠炎（UC）的实验模型中，针灸能下调炎症细胞因子的表达，增加IL-10的表达，改善Treg细胞的分化，还能调节RA和UC模型中巨噬细胞的极化。针灸对自身免疫性疾病的抗炎作用已被证实涉及迷走神经-肾上腺和胆碱能抗炎通路。针灸的镇痛作用涉及外周和中枢的抗痛觉机制。随机对照研究支持针灸用于类风湿性关节炎、纤维肌痛、克罗恩病和 Sjogren's 综合征。一些证据表明，针灸对多发性硬化症、重症肌无力、银屑病和强直性脊柱炎的对症治疗可能有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.