Dual Role of Choline Azide for One-Pot Synthesis of Quinolines and Quinazolines Using Versatile Magnetic Cu-Oxalate@Fe3O4 Catalyst

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL

Catalysis Letters Pub Date : 2024-11-25 DOI:10.1007/s10562-024-04856-y

Akshay S. Limaye, R. Thrilokraj, Shoyebmohamad F. Shaikh, Umesh A. Kshirsagar, Jan Grzegorz Małecki, Abdullah M. Al-Enizi, Pravin Y. Kogale, Ramesh B. Dateer

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Abstract

The present study demonstrates biogenically synthesized copper-oxalate supported on iron oxide (Fe₃O₄) and its implementation for pharmaceutically important quinoline and quinazoline synthesis. The formation of a new catalyst was confirmed by Field emission scanning electron microscope (FE-SEM) and Brunauer–Emmett–Teller (BET) analysis that displayed a spherical shape with a surface area of 18.407 m² g⁻¹, and an active metal concentration of 12.02 w/w%. The dual role of choline azide as a green solvent as well as a nitrogen source is demonstrated and a series of quinoline and quinazoline derivatives were synthesized in good to excellent yield. Importantly, catalyst recyclability, mechanistic investigations, control experiments, and reaction economy highlight the importance of methodology.

Graphical Abstract

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利用多功能磁性 Cu-Oxalate@Fe3O4 催化剂一锅合成喹啉和喹唑啉时叠氮化胆碱的双重作用

本研究展示了生物合成的以氧化铁（Fe3O4）为载体的铜草酸盐，并将其用于具有重要药用价值的喹啉和喹唑啉的合成。场发射扫描电子显微镜（FE-SEM）和布鲁瑙尔-艾美特-泰勒（BET）分析证实了新催化剂的形成，该催化剂呈球形，表面积为 18.407 m2 g-1，活性金属浓度为 12.02 w/w%。叠氮化胆碱作为绿色溶剂和氮源的双重作用得到了证实，并合成了一系列喹啉和喹唑啉衍生物，收率从良好到极佳。重要的是，催化剂的可回收性、机理研究、控制实验和反应经济性凸显了方法学的重要性。

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来源期刊

Catalysis Letters 化学-物理化学

CiteScore

5.70

自引率

3.60%

发文量

327

审稿时长

1 months

期刊介绍： Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis. The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.