[Advances in the application of live bacteria as vehicles for delivering antitumor drugs].

Q4 Biochemistry, Genetics and Molecular Biology
Tingting Hua, Bin Zheng, Yang Bai
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引用次数: 0

Abstract

Some bacteria can selectively colonize the tumor site and inhibit tumor growth, serving as ideal vehicles for delivering antitumor drugs. The system of delivering antitumor drugs with live bacteria as vehicles is characterized by good biocompatibility and precise targeting. However, the development of bacteria as drug delivery vehicles is limited by their own immunogenicity. In this paper, the selection of chassis bacteria, bacterial loading drug strategies, antitumor drug delivery applications and their limitations are elaborated in detail, and its future development direction is envisioned, with a view to providing a reference for the study of live bacteria as antitumor drug delivery carriers.

[活细菌作为抗肿瘤药物载体的应用进展]。
一些细菌可选择性地定植于肿瘤部位并抑制肿瘤生长,是输送抗肿瘤药物的理想载体。以活细菌为载体的抗肿瘤药物递送系统具有良好的生物相容性和精确靶向性。然而,细菌自身的免疫原性限制了其作为给药载体的发展。本文详细阐述了底盘细菌的选择、细菌载药策略、抗肿瘤药物递送应用及其局限性,并展望了其未来的发展方向,以期为活菌作为抗肿瘤药物递送载体的研究提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Sheng wu gong cheng xue bao = Chinese journal of biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.50
自引率
0.00%
发文量
298
期刊介绍: Chinese Journal of Biotechnology (Chinese edition) , sponsored by the Institute of Microbiology, Chinese Academy of Sciences and the Chinese Society for Microbiology, is a peer-reviewed international journal. The journal is cited by many scientific databases , such as Chemical Abstract (CA), Biology Abstract (BA), MEDLINE, Russian Digest , Chinese Scientific Citation Index (CSCI), Chinese Journal Citation Report (CJCR), and Chinese Academic Journal (CD version). The Journal publishes new discoveries, techniques and developments in genetic engineering, cell engineering, enzyme engineering, biochemical engineering, tissue engineering, bioinformatics, biochips and other fields of biotechnology.
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