Survival and biomarker analysis for cancer‑associated thromboembolism in ovarian clear cell carcinoma.

Abstract

The present study aimed to investigate the impact of cancer-associated thromboembolism (CAT) on the survival and biomarkers of ovarian clear cell carcinoma (OCCC). Patients with OCCC who underwent surgery at the National Defense Medical College Hospital (Tokorozawa, Japan) between January 2000 and December 2019 were included in the current study. Associations among CAT, clinicopathological features and prognosis were retrospectively compared. Furthermore, immunohistochemical staining was conducted in all patients to compare differences between patients with and without CAT. Among 111 patients with OCCC, 20 patients (18.0%) had CAT complications. CAT was detected in 12 patients (10.8%) before primary treatment and in 8 patients (7.2%) after primary surgery. Patients with CAT experienced more tumor recurrence (P=0.048) and platinum resistance (P=0.025), had worse progression-free survival (PFS; P<0.01) and overall survival (OS; P<0.01), and multivariate analysis showed that CAT was a prognostic factor for worse PFS [hazard ratio (HR)=2.10, P=0.039] and OS (HR=4.26, P<0.01). Moreover, immunohistochemical analysis revealed that more OCCC cases with CAT were positive for tissue factor (TF; P=0.030) and phosphorylated-Janus kinase 2 (JAK2; P=0.034) expression than those without CAT. In conclusion, CAT may be associated with platinum resistance and poor prognosis in patients with OCCC. Furthermore, TF and JAK2 could be considered potential novel therapeutic targets for OCCC complicated by CAT.