[Research progress in the translation efficiency of mRNA vaccines].

Q4 Biochemistry, Genetics and Molecular Biology

Sheng wu gong cheng xue bao = Chinese journal of biotechnology Pub Date : 2024-11-25 DOI:10.13345/j.cjb.240193

Tao Liu, Shengqi Wang, Wuju Li

引用次数: 0

Abstract

Compared with conventional vaccines, mRNA vaccines have considerable advantages in design, production, and application, especially in dealing with emerging infectious diseases. Particularly, mRNA vaccines were the first to be recommended by the World Health Organization for emergency use during the COVID-19 pandemic. A key to the design of mRNA vaccines is to ensure the stable and sufficient expression of the encoded protein in the recipient. In recent years, advances have been attained in the experimental and computational research in this area. This review focused on the progress and problems in improving the translation efficiency of mRNA vaccines in recent years, aiming to promote related research.

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[mRNA 疫苗翻译效率的研究进展]。

与传统疫苗相比，mRNA 疫苗在设计、生产和应用方面具有相当大的优势，尤其是在应对新出现的传染病方面。特别是在 COVID-19 大流行期间，mRNA 疫苗率先被世界卫生组织推荐用于紧急接种。设计 mRNA 疫苗的关键在于确保受体能稳定、充分地表达编码蛋白。近年来，这一领域的实验和计算研究取得了进展。本综述重点介绍了近年来在提高 mRNA 疫苗翻译效率方面取得的进展和存在的问题，旨在促进相关研究的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sheng wu gong cheng xue bao = Chinese journal of biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

1.50

自引率

0.00%

发文量

298

期刊介绍： Chinese Journal of Biotechnology (Chinese edition) , sponsored by the Institute of Microbiology, Chinese Academy of Sciences and the Chinese Society for Microbiology, is a peer-reviewed international journal. The journal is cited by many scientific databases , such as Chemical Abstract (CA), Biology Abstract (BA), MEDLINE, Russian Digest , Chinese Scientific Citation Index (CSCI), Chinese Journal Citation Report (CJCR), and Chinese Academic Journal (CD version). The Journal publishes new discoveries, techniques and developments in genetic engineering, cell engineering, enzyme engineering, biochemical engineering, tissue engineering, bioinformatics, biochips and other fields of biotechnology.