Predictive value of percutaneous peripheral arterial compliance T in left ventricular diastolic function with coronary artery disease.

IF 2.8 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Frontiers in Cardiovascular Medicine Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI:10.3389/fcvm.2024.1366072
Wenhao Zhang, Guoliang Liang, Liang Lv, Xinxin Gu, Qiong Zhang, Ankang Liu, Jiangwei Ma
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引用次数: 0

Abstract

Background: Diastolic dysfunction emerges early in patients with cardiac insufficiency and is prevalent, underscoring the importance of its early identification and intervention in the prevention of heart failure. The study leverages the convenience and accuracy of measuring peripheral arterial sclerosis to facilitate the early detection of diastolic dysfunction, which is instrumental in mitigating and delaying the onset and progression of heart failure, holding significant clinical relevance.

Methods: This research enrolled 556 patients suspected of experiencing Acute Coronary Syndrome (ACS) and stratified them into Groups A, B, C, and D according to the severity of coronary artery stenosis. The diastolic function of the left ventricle was indicated by the relaxation time constant, denoted as T value, which measures the temporal span from the peak rate of left ventricular pressure rise (dp/dt) to the end-diastolic pressure.

Results: The T value of the left ventricle demonstrated a significant correlation with the Gensini Score and the T values across various peripheral arteries (P < 0.01). Pearson correlation analysis showed that the average value of peripheral arterial compliance indices in Group C and the average value of peripheral arterial compliance indices in Group D had a significant correlation with LV-T. At the same time, linear analysis of the average values of peripheral arterial compliance indices in both groups revealed that the average compliance indices in Groups C and D had a linear correlation with their LV-T (P < 0.05).When coronary artery stenosis exceeds 50%, the changes in peripheral arterial T values are significantly correlated with changes in LV-T.

Conclusions: When coronary artery stenosis exceeds 50%, there is a decrease in peripheral artery compliance, showing a positive correlation with changes in left ventricular diastolic function. Measuring this compliance might offer an early diagnostic tool for assessing diastolic function.

经皮外周动脉顺应性 T 对冠心病左心室舒张功能的预测价值。
背景:舒张功能障碍在心功能不全患者中出现较早且普遍,这凸显了早期识别和干预对预防心衰的重要性。该研究利用测量外周动脉硬化的便利性和准确性,促进舒张功能障碍的早期发现,这对减轻和延缓心衰的发生和发展至关重要,具有重要的临床意义:该研究共纳入 556 名疑似急性冠状动脉综合征(ACS)患者,并根据冠状动脉狭窄的严重程度将其分为 A、B、C 和 D 组。左心室舒张功能由舒张时间常数(用 T 值表示)表示,它测量了从左心室压力上升峰值速率(dp/dt)到舒张末压的时间跨度:当冠状动脉狭窄超过 50%时,外周动脉顺应性会下降,与左心室舒张功能的变化呈正相关。测量这种顺应性可作为评估舒张功能的早期诊断工具。
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来源期刊
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.80
自引率
11.10%
发文量
3529
审稿时长
14 weeks
期刊介绍: Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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