Risk of Stroke or Heart Attack in Mild Cognitive Impairment and Subjective Cognitive Impairment.

IF 3.2 Q2 CLINICAL NEUROLOGY

Neurology International Pub Date : 2024-11-19 DOI:10.3390/neurolint16060113

Michele Lauriola, Luigi Esposito, Grazia D'Onofrio, Filomena Ciccone, Annamaria la Torre, Filomena Addante, Annagrazia Cocomazzi, Leandro Cascavilla, Olga Ariano, Gaetano Serviddio, Antonio Greco

{"title":"Risk of Stroke or Heart Attack in Mild Cognitive Impairment and Subjective Cognitive Impairment.","authors":"Michele Lauriola, Luigi Esposito, Grazia D'Onofrio, Filomena Ciccone, Annamaria la Torre, Filomena Addante, Annagrazia Cocomazzi, Leandro Cascavilla, Olga Ariano, Gaetano Serviddio, Antonio Greco","doi":"10.3390/neurolint16060113","DOIUrl":null,"url":null,"abstract":"Background: The study aimed to identify Mild Cognitive Impairment (MCI) as an alert clinical manifestation of increased probability of major acute vascular events (MVEs), such as Ischemic Stroke and heart attack.Methods: In a longitudinal study, 181 (M = 81, F = 100; mean age of 75.8 ± 8.69 years) patients were enrolled and divided into three groups based on diagnosis: Subjective Cognitive Impairment (SCI), amnestic MCI Single Domain (aMCI-SD), and amnestic MCI More Domain (aMCI-MD). Clinical assessment and the presence of vascular risk factors were collected.Results: The distribution of MVEs showed a higher incidence in the first two years of follow-up of 7.4% in SCI, 12.17% in aMCI-SD, and 8.57% in aMCI-MD. Acute Myocardial Infarction showed a major incidence in one year of follow-up (41%) and in two years of follow-up (29%). Also, Ischemic Stroke showed a major incidence in one year of follow-up (30%) and in two years of follow-up (40%). A statistically significant difference in the progression to dementia was shown (SCI 3.75%; aMCI-SD 10.43%; aMCI-MD 37%; p-value < 0.001).Conclusions: MCI is considered an expression of the systemic activation of mechanisms of endothelial damage, representing a diagnosis predictive of increased risk of MVEs.","PeriodicalId":19130,"journal":{"name":"Neurology International","volume":"16 6","pages":"1528-1539"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587450/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/neurolint16060113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The study aimed to identify Mild Cognitive Impairment (MCI) as an alert clinical manifestation of increased probability of major acute vascular events (MVEs), such as Ischemic Stroke and heart attack.

Methods: In a longitudinal study, 181 (M = 81, F = 100; mean age of 75.8 ± 8.69 years) patients were enrolled and divided into three groups based on diagnosis: Subjective Cognitive Impairment (SCI), amnestic MCI Single Domain (aMCI-SD), and amnestic MCI More Domain (aMCI-MD). Clinical assessment and the presence of vascular risk factors were collected.

Results: The distribution of MVEs showed a higher incidence in the first two years of follow-up of 7.4% in SCI, 12.17% in aMCI-SD, and 8.57% in aMCI-MD. Acute Myocardial Infarction showed a major incidence in one year of follow-up (41%) and in two years of follow-up (29%). Also, Ischemic Stroke showed a major incidence in one year of follow-up (30%) and in two years of follow-up (40%). A statistically significant difference in the progression to dementia was shown (SCI 3.75%; aMCI-SD 10.43%; aMCI-MD 37%; p-value < 0.001).

Conclusions: MCI is considered an expression of the systemic activation of mechanisms of endothelial damage, representing a diagnosis predictive of increased risk of MVEs.

查看原文本刊更多论文

轻度认知障碍和主观认知障碍患者中风或心脏病发作的风险。

研究背景该研究旨在确定轻度认知功能障碍（MCI）是缺血性中风和心脏病发作等重大急性血管事件（MVEs）发生概率增加的警示性临床表现：在一项纵向研究中，共招募了 181 名患者（男 = 81，女 = 100；平均年龄为 75.8 ± 8.69 岁），并根据诊断结果分为三组：主观认知障碍组（SCI）、失忆性 MCI 单领域组（aMCI-SD）和失忆性 MCI 多领域组（aMCI-MD）。研究人员还收集了临床评估和血管风险因素的存在情况：MVEs的分布情况显示，在随访的头两年中，SCI的发病率较高，为7.4%，aMCI-SD为12.17%，aMCI-MD为8.57%。急性心肌梗死在随访一年（41%）和随访两年（29%）的发病率较高。此外，缺血性脑卒中也是随访一年（30%）和随访两年（40%）的主要发病率。从统计学角度看，痴呆症的发病率存在明显差异（SCI 3.75%；aMCI-SD 10.43%；aMCI-MD 37%；P 值<0.001）：MCI被认为是内皮损伤机制系统激活的一种表现形式，是预测MVE风险增加的一种诊断方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊